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Letters to the Editor
September 2001

Neuropathologic Correlates of Dysarthria in Progressive Supranuclear Palsy

Arch Neurol. 2001;58(9):1499-1500. doi:

Kluin et al,1 comparing dysarthria with neuropathological findings in 14 patients with postmortem-confirmed progressive supranuclear palsy (PSP), reported significant correlations between the severity of hypokinetic dysarthria and the degree of semiquantitatively assessed neuronal loss and gliosis in the substantia nigra pars compacta (SNC) and substantia nigra pars reticulata (SNR) but not in the subthalamic nucleus, striatum, or globus pallidus, while the spastic and ataxic components of dysarthria did not correlate with histopathological changes in the frontal cortex or cerebellum. These data can be confirmed by the findings in a cohort of 16 autopsy cases of PSP from the research files of the Ludwig Boltzmann Institute of Clinical Neurobiology, Vienna, Austria, some of which were included in a clinicopathological study of 21 cases2 and in a recent study on the progression of dysarthria and dysphagia in postmortem-confirmed parkinsonian disorders.3

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