YOUR PATIENT is a 61-year-old man with the slow onset of some recent stiffness predominantly in the left arm and hand, some clumsiness when walking, and a slight pill-rolling tremor of the left hand. Further physical examination is consistent with the diagnosis of early Parkinson disease (PD). Magnetic resonance imaging and ligand-specific positron emission tomography studies confirm the diagnosis. Examination of the polymorphic variations of the parkin gene and the other major PD susceptibility genes determines PD type 7, which has a mean age of onset of 61 to 64 years.
Roses AD. 2025: The Practice of NeurologyBack From the Future. Arch Neurol. 2001;58(11):1766–1767. doi:10.1001/archneur.58.11.1766
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