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February 2003

Apolipoprotein E, Alzheimer Disease, and African Americans

Arch Neurol. 2003;60(2):161-163. doi:10.1001/archneur.60.2.161

APOLIPOPROTEIN E (APOE) is the most upstream member of a large cluster of apolipoprotein genes that are coregulated, at least in the liver and kidneys, by the interaction of the individual gene promoters with a set of shared enhancer elements.1APOE has been extensively investigated because of its role in lipid metabolism and ischemic cardiovascular disease,2-5 but more recently because of its association with Alzheimer disease. In addition to Alzheimer disease and heart disease, the variants of APOE have also been associated with cerebral hemorrhage accompanying amyloid angiopathy and longevity.6,7

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