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April 2003

Unexplained Sudden Amnesia, Postencephalitic Parkinson Disease, Subacute Sclerosing Panencephalitis, and Alzheimer Disease: Does Viral Synergy Produce Neurofibrillary Tangles?

Arch Neurol. 2003;60(4):641-642. doi:10.1001/archneur.60.4.641

The comprehensive and intriguing report of 2 rare cases of sudden amnesia occurring as a result of some unrecognized pathophysiological process1 may offer further tantalizing evidence that a smoldering viral encephalitis with a predilection for mesial temporal lobes, perhaps reflecting synergistic interaction between influenza virus and herpes simplex virus type 1, could eventuate in Alzheimer disease.