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June 2003

Cerebrospinal Fluid 14-3-3 ProteinVariability of Sporadic Creutzfeldt-Jakob Disease, Laboratory Standards, and Quantitation

Arch Neurol. 2003;60(6):803-804. doi:10.1001/archneur.60.6.803

THE CONCENTRATION in cerebrospinal fluid (CSF) of a constitutive neuronal protein known as 14-3-3 protein has been noted to be increased in patients with Creutzfeldt-Jakob disease (CJD).1,2 A study in this month's ARCHIVES3 challenges the clinical utility of using elevated 14-3-3 protein levels as confirmation for diagnosis of sporadic CJD. This important study points out flaws in the clinical application of this laboratory analysis for CSF proteins that are not pathogenetically linked to the underlying disorder.

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