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Editorial
February 2004

Fatigue in Multiple Sclerosis: Is the Picture Getting Simpler or More Complex?

Arch Neurol. 2004;61(2):176-177. doi:10.1001/archneur.61.2.176

Fatigue is one of the most common and disabling symptoms of multiple sclerosis (MS).1 Not only does fatigue affect up to 87% of patients with MS but as many as 40% of patients with MS regard fatigue to be their most disabling symptom.2 Although several therapies have shown some promise in the treatment of fatigue in patients with MS, the lack of a truly effective treatment for this symptom may be due to the underlying pathophysiology for MS fatigue still being debated.

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