Copyright 2004 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2004
One of the major discoveries in dementia has been the linkage of a family with disinhibition-dementia-parkinsonism amyotrophy complex to chromosome 17.1 Soon after that, several other families were linked to chromosome 17, many described before, under various names, such as hereditary dysphasic dementia2 and pallido-ponto-nigral degeneration.3 It was soon recognized that all these conditions have clinical and pathological resemblance to sporadic frontotemporal dementia (FTD), primary progressive aphasia, and corticobasal ganglionic degeneration (CBD). A conference about chromosome 17–linked dementias agreed on the apt term frontotemporal dementia with parkinsonism linked to chromosome 17.4 Although Wilhelmsen considered tau the candidate gene, tau mutations were described later.5,6
Kertesz A. A Frontotemporal Family Bridge. Arch Neurol. 2004;61(3):318. doi:10.1001/archneur.61.3.318
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