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March 2004

Juvenile Parkinson Disease and the C212Y Mutation of Parkin

Arch Neurol. 2004;61(3):444. doi:10.1001/archneur.61.3.444-a

An ARCHIVES article by Hoenicka et al1 describes the molecular characterization of families from Spain with juvenile Parkinson disease. The authors claim to have identified a novel disease-causing mutation leading to a C212Y substitution in the parkin protein. I would like to point out that we had already described this mutation in juvenile Parkinson disease pedigrees from Colombia,2 and therefore its observation in Spanish patients is not really an original contribution. It is unfortunate that Hoenicka and colleagues were not aware of our publication because the presence of the same mutation in families from Colombia and Spain is interesting. It would be particularly intriguing to know if this observation represents a recurrent event or results from migration between these 2 historically related populations.

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