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History of Neurology
May 2004

The Aura-Headache Connection in Migraine: A Historical Analysis

Author Affiliations

Copyright 2004 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2004

Arch Neurol. 2004;61(5):794-799. doi:10.1001/archneur.61.5.794

A historical analysis is presented of insights into the pathogenetic mechanisms related to the migraine aura and headache and how the mechanisms connect. In the traditional sequential concept, advanced through the work of Edward Liveing, MD, Harold G. Wolff, MD, and others, the mechanisms are considered causally connected. A noncausal, parallel concept has been proposed as well and is considered in light of the results of recent animal experimental studies.