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Book Reviews
June 2004

Multiple Sclerosis: Immunology, Pathology, and Pathophysiology

Author Affiliations


Arch Neurol. 2004;61(6):978-979. doi:10.1001/archneur.61.6.978-b

edited by Robert M. Herndon, MD, 258 pp, with illus, $89.95, ISBN 1-888799-62-5, New York, NY, Demos Medical Publishing, Inc, 2003.

One is struck when opening this book by the dedication to 3 leaders in the field of multiple sclerosis (MS) who tragically had nearly simultaneous untimely deaths in 2001: Larry Jacobs, MD ("The Jake"), John Whitaker, MD, and John Trotter, MD. The memory of these 3 outstanding individuals provides a compelling backdrop against which to tackle the important basic science issues of MS and its pathophysiologic characteristics. The book remains true to the trail blazed by these giants as it provides an overview of immunologic features, pathologic characteristics, and experimental models of MS. The editor has brought together accomplished researchers and physicians from various disciplines in the allied neuroscience community to provide a unique and authoritative review. A reading of the author affiliations shows representation from neurology, pathology, microbiology, neuroscience, immunology, and imaging. One theme that resonates clearly is the need for a multidisciplinary approach to studying this interesting and complex disease. Such collaboration forms the basis of the most successful MS research programs.

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