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Editorial
July 2004

Genes for Movement

Arch Neurol. 2004;61(7):1006. doi:10.1001/archneur.61.7.1006

In 1940, Mount and Reback1 described familial paroxysmal choreoathetosis in a report in the ARCHIVES, more than 60 years ago. Known also as paroxysmal dystonic choreoathetosis (PDC) (Mendelian Inheritance in Man No. 11880) and paroxysmal nonkinesigenic dyskinesia, it is a movement disorder in which episodes of dystonia, chorea, and athetosis begin in childhood through early adulthood; involve the extremities, trunk, and face; and may be associated with dysarthria and dysphagia. These episodes are of varying lengths—from minutes to an hour—and may recur several times a day. Paroxysmal movements may occur spontaneously while at rest or may be precipitated by alcohol or caffeine use, fatigue, hunger, or emotional stress.

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