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August 2004

Haplotype-Phenotype Correlations in Kindreds With the N279K Mutation in the Tau Gene

Arch Neurol. 2004;61(8):1327. doi:10.1001/archneur.61.8.1327-a

The recent article by Soliveri et al1 identifies an Italian kindred with frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) with the N279K mutation. The clinical phenotype is similar to that described in other kindreds with the N279K mutation, with prominent parkinsonism and personality changes early in the course of the disease.2