A 47-year-old man was admitted for facial bone surgery after a mandibular fracture. Anesthesia was induced with thiopental sodium following succinylcholine administration. Intubation was performed without difficulty and anesthesia was maintained with enflurane and nitrous oxide.
Near the end of the procedure, his heart rate increased gradually to 120/min and his rectal temperature rose rapidly to 42°C. There was no evidence of external bleeding and blood pressure was maintained between 120/80 and 100/70 mm Hg. Malignant hyperthermia was tentatively diagnosed and surgery was stopped. The patient was placed in an ice pack, treated with intravenous dantrolene, and hyperventilated with 100% oxygen.
Park J, Choi Y, Park S, Kim Y, Lee K. Magnetic Resonance Imaging Reveals Selective Vulnerability of the Cerebellum and Basal Ganglia in Malignant Hyperthermia. Arch Neurol. 2004;61(9):1462–1463. doi:10.1001/archneur.61.9.1462
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: