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Letters to the Editor
January 2005

The Heterogeneity and Natural History of Mild Cognitive Impairment

Arch Neurol. 2005;62(1):163. doi:10.1001/archneur.62.1.163-a

Mild cognitive impairment (MCI) is a controversial entity. To date, enthusiasts of the MCI concept have supported their view with the finding of consistently higher incidence of Alzheimer disease in persons with MCI than in persons without MCI, while detractors have stressed that a large proportion of patients with MCI do not progress even after long follow-up periods. Maruyama et al1 have recently reported in the ARCHIVES some findings that reconcile these opposing views by shedding light on the natural history of MCI subtypes. However, some inconsistencies with data from the literature deserve comment.