Copyright 2005 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2005
Hutchinson and Lebedev have chosen to ignore an essential paragraph on page 1058 of our article. With respect, we quote part of it here again: “It is difficult to demonstrate directly that a group of individuals constitute a cluster in time and space with respect to a disease. In addition to the obvious problem of ascertainment bias associated with the retrospective identification of such groups and the difficulty of defining a suitable control framework for the purposes of comparison, there is a major logical barrier to our attempt to prove the hypothesis that the group constitutes a meaningful cluster.”
Kumar A, Calne S, Schulzer M, et al. On the Use of Clusters to Determine Environmental Influence on Disease—Reply. Arch Neurol. 2005;62(2):331–332. doi:10.1001/archneur.62.2.331-b
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