The editors and editorial board of the Archives of Neurology are implementing the requirement that all clinical trials be registered in a public trials registry as a condition for consideration for publication. This implementation is in support of the plan published by JAMA editor Catherine D. DeAngelis, MD, and editors from the International Committee of Medical Journal Editors (ICMJE) regarding clinical trial registration.1 The ICMJE has recognized the need for device manufacturers and pharmaceutical corporations to register all clinical trials involving human subjects before recruiting participants.