We read with interest the report of patients with splenium of corpus callosum (SCC) lesions, most being reversible with transiently reduced apparent diffusion coefficient (ADC) values.1 We previously described 15 patients with clinically mild encephalitis/encephalopathy with identical reversible SCC lesions,2 and we postulated that intramyelinic edema due to separation of myelin layers was a possible mechanism for the transiently decreased ADC. We recently saw a neonate with an identical SCC lesion, suggesting that the mechanism underlying the lesion might not be related to myelination.
Takanashi J, Maeda M, Hayashi M. Neonate Showing Reversible Splenial Lesion. Arch Neurol. 2005;62(9):1481–1482. doi:10.1001/archneur.62.9.1481