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February 2006

Gambling and Parkinson Disease

Arch Neurol. 2006;63(2):298. doi:10.1001/archneur.63.2.298-a

The article by Dodd et al1 described 11 patients with Parkinson disease who developed pathological gambling. The authors concluded that because pramipexole was the agonist involved in 9 of the 11 cases, and in 10 of 17 cases reported in the literature, pramipexole may result in gambling to a higher degree as compared with the other agonists, due to its disproportionate stimulation of dopamine D3 receptors.

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