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Editorial
April 2006

Frontotemporal Lobar Degeneration With Motor Neuron Disease: A Clinical and Pathological Spectrum

Author Affiliations
 

Copyright 2006 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2006

Arch Neurol. 2006;63(4):489-490. doi:10.1001/archneur.63.4.489

Frontotemporal lobar degeneration (FTLD) is second only to Alzheimer disease as a cause of progressive cognitive impairment. The diagnostic category encompasses a phenotypic and pathologically heterogeneous group of disorders that begs to be split into distinct, clinically recognizable units. The clinical phenotype involves a variable spectrum of impairments in behavior and language, psychiatric symptoms, and motor signs in pyramidal and extrapyramidal systems.1-3

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