Five hundred eighty-six patients with epilepsy were treated with borax (hydrated sodium tetraborate) between 1912 and 1948 at the Kolonien Filadelfia Epilepsy Hospital, Dianalund, Denmark. A rough estimation shows that less than 5% experienced a more than 50% reduction in the total number of seizures. Charts were reviewed to find a connection between the concept of Bacillus epilepticus (1916) and the so-called renaissance of borax treatment described in 1923, and to find an explanation for the popularity of this seemingly ineffective antiepileptic drug.
John P. A. Jensen. The Rise and Fall of Borax as an Antiepileptic Drug. Arch Neurol. 2006;63(4):621–622. doi:10.1001/archneur.63.4.621