We describe a primary cerebral amyloidoma that mimicked high-grade glioma on neuroimaging. Histologic analysis confirmed amyloidoma. Because neuroimaging characteristics of intracerebral amyloidoma can be confused for high-grade glioma, these lesions must be confirmed histologically before initiating aggressive treatment for presumptive high-grade glioma.
Amyloidosis is a diverse group of acquired or hereditary diseases characterized by extracellular tissue deposits of insoluble proteins in 1 or several organs. The defining feature of amyloidomas is the localized tumorlike deposition of amyloid.