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December 2006

Data vs Conclusions in the Optic Neuritis Vaccination Investigation

Arch Neurol. 2006;63(12):1809-1810. doi:10.1001/archneur.63.12.1809

Regarding the study of vaccinations and subsequent optic neuritis by the Centers for Disease Control and Prevention (CDC),1 the authors made a curious choice of statistical methods. They had access to the Defense Medical Surveillance System (DMSS), an extremely rich database that includes all immunizations, diagnoses for all inpatient and outpatient medical encounters, and additional information for more than 10 million military person-years.