Use of the DMSS database has allowed the largest vaccine safety investigation of optic neuritis ever published; the power to detect an odds ratio of 1.4 for this study's 18-week study interval was high (>0.80). The matched case-control study design is widely regarded as appropriate for investigations of rare diseases such as optic neuritis; a case-control design was used by researchers in another large vaccine safety investigation of optic neuritis.1
Payne DC, Rose CE, Kerrison J, Aranas A, Duderstadt S, McNeil MM. Data vs Conclusions in the Optic Neuritis Vaccination Investigation—Reply. Arch Neurol. 2006;63(12):1810. doi:10.1001/archneur.63.12.1810
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