With interest we read the article by van der Kooi et al1 on cardiac involvement (CI) and pulmonary involvement of 50 patients with Bethlem myopathy (BMP). The article raises concerns.
Which other risk factors for atherothrombosis in addition to arterial hypertension were present among the included patients? How many had diabetes mellitus, hyperlipidemia, thyroid dysfunction, or a history of myocardial infarction or rhythm abnormalities, and how many were smokers or obese? How many had undergone stress tests or coronary angiography? The cardiac abnormalities described may be simply attributable to coronary artery disease.
Finsterer J, Stöllberger C. Cardiac Involvement in Bethlem Myopathy. Arch Neurol. 2007;64(6):915. doi:10.1001/archneur.64.6.915-a
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