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Book Reviews
August 2007

Transcription Factors of the Nervous System: Development, Brain Function, and Diseases

Arch Neurol. 2007;64(8):1204-1205. doi:10.1001/archneur.64.8.1204

edited by Gerald Thiel, PhD, 445 pp, with illus, $219, ISBN 3-527-31285-4, Wiley-VCH, Weinheim, Germany, 2006.

It is difficult to encompass within a single volume the expanding complexity of a topic as broad as the one outlined in this monograph. Because 5% of the genome is composed of genes that encode transcription factors (TFs) and more than 300 are present during mouse development (both statements made in the volume's preface), a discussion of all of these (or even all that have been more than vaguely analyzed) is beyond the scope of a single book. Having said this, the current volume succeeds in providing a well-described, aptly organized collection of most of the major TFs in brain development and function as written by many of the leaders in the field.