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December 2007

More on Multiple Sclerosis and Neuromyelitis Optica—Reply

Author Affiliations

Copyright 2007 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2007

Arch Neurol. 2007;64(12):1802-1803. doi:10.1001/archneur.64.12.1802-b

In reply

We have reviewed the interesting comments of Franciotta et al, who propose that MS and NMO may be distinguished by biologic differences in their respective humoral immune responses: oligoclonal banding, anti-aquaporin-4 (AQP-4) specificity, and background polyreactivity. Given the differing views of the authors13 on the distinctness of NMO and MS, as expressed in our recent “Controversies in Neurology” series, understandably we will express somewhat disparate responses to these comments.

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