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Book Reviews
October 2008

Clinical Diagnosis and Management of Alzheimer’s Disease, 3rd ed

Arch Neurol. 2008;65(10):1392-1394. doi:10.1001/archneur.65.10.1392-b

The Clinical Diagnosis and Management of Alzheimer's Disease,edited by Serge Gauthier, appeared in its third edition in 2007. In this review, we will consider the march of progress and expectations for future advances by comparing the previous 2 editions, which appeared in 1996 and 1999, with the current edition.

Over this 12-year span, much has remained the same in both the book and the field. The edition has continued to be structured around 6 headings and is approximately the same length, although 5 new chapters have been added that illuminate several changes in the field. Perhaps the greatest change has been in the chapters having to do with diagnosis and drug treatment, given the medical flavor of this book. In 1996, a single drug, tacrine, had been approved to treat dementia, and accordingly, the first-edition therapeutic chapter illustrated the struggles with both the development and use of this drug in clinical practice. Even in 1996, however, expectations were growing that disease-modifying therapies might emerge. The publication of the 1999 edition seems to be motivated by this sense that more powerful therapies would soon be delivered into practice.

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