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Images in Neurology
October 2009

Stroke Incidentally Identified Using Improved Positron Emission Tomography for Microglial Activation

Arch Neurol. 2009;66(10):1288-1289. doi:10.1001/archneurol.2009.208

A 42-year-old man enrolled in a research study to measure microglial activation using [O-methyl-11C] N-acetyl-N-(2-methoxybenzyl)-2-phenoxy-5-pyridinamine ([11C]PBR28), an improved positron emission tomography (PET) radioligand. His history included human immunodeficiency virus infection, diabetes, hypertension, hypercholesterolemia, smoking (12 pack-years), and remote use of cocaine and heroin. Medical and neurological examination results were normal except for elevated blood pressure of 157/100 mm Hg. Brain magnetic resonance imaging (MRI) showed occasional foci of mild chronic white matter ischemia but was otherwise unremarkable (Figure, A).

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