There is increasing emphasis on interdisciplinary translation in biomedical research.1 A major push toward prevention of Alzheimer disease (AD) is spawning translational research2 that should span basic, clinical, and population investigations. Epidemiological studies, which address our understanding of risk and protective factors for disease at the population level, are contributing less than they could to translational research. In part, this is because the key concept of risk is being “lost in translation,” muddling interpretations and leading to interdisciplinary frustrations. As epidemiologists, we offer a framework for resolving some of the confusion.
Ganguli M, Kukull WA. Lost in TranslationEpidemiology, Risk, and Alzheimer Disease. Arch Neurol. 2010;67(1):107–111. doi:10.1001/archneurol.2009.311