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February 2010

Progress on Progranulin

Author Affiliations

Author Affiliations: Department of Neurology, Mayo Clinic, Rochester, Minnesota.

Arch Neurol. 2010;67(2):145-147. doi:10.1001/archneurol.2009.320

Advances in molecular genetics and molecular biology have greatly expanded our knowledge of the disorders and the associated dysfunctional proteins that manifest as dementia, parkinsonism, and/or amyotrophic lateral sclerosis (ALS) and are encompassed by the term frontotemporal lobar degeneration (FTLD). The most relevant genes and their associated critical features are presented in the Table.17

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