Advances in molecular genetics and molecular biology have greatly expanded our knowledge of the disorders and the associated dysfunctional proteins that manifest as dementia, parkinsonism, and/or amyotrophic lateral sclerosis (ALS) and are encompassed by the term frontotemporal lobar degeneration (FTLD). The most relevant genes and their associated critical features are presented in the Table.1- 7
Boeve BF. Progress on Progranulin. Arch Neurol. 2010;67(2):145–147. doi:10.1001/archneurol.2009.320
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