Such knowledge as we have of these steps is derived from casual glimpses afforded when, as the outcome of one of Nature’s experiments, some particular line is interfered with . . .—Archibald E. Garrod, Inborn Errors of Metabolism
Arterial tortuosity and dilatation has usually been called dolichoectasia, a term used to describe marked elongation, widening, and tortuosity of arteries. Because dilatation is the most important feature, the condition is now often referred to as dilatative arteriopathy.1 Approximately 1 patient in 8 who underwent intracranial vascular imaging has some increase in the length and diameter of intracranial arteries.2,3 The prevalence of intracranial dolichoectasia is approximately 0.1% to 5.8% among the general population.4-6 The intracranial vertebrobasilar arteries are most often and most severely involved. The cervical arteries may also be loopy and dilated. The changes in the brain-supplying cervicocranial arteries are often accompanied by dilatation of the aorta3 and the coronary arteries7 and by abnormalities within the small penetrating arteries within the brain.8
Caplan LR. On Curves, Bends, Blisters, and Strokes. Arch Neurol. 2011;68(3):292–293. doi:10.1001/archneurol.2011.24
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