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January 2022, Vol 79, No. 1, Pages 5-93

Viewpoint

Neuro-Advocacy—Professionalism in Action

Abstract Full Text
JAMA Neurol. 2022;79(1):7-8. doi:10.1001/jamaneurol.2021.4049

This Viewpoint encourages physicians to participate in neuro-advocacy to promote legislation and policy that can positively affect persons with neurologic disease and the practice of neurology and facilitate neuroscience research.

On Cave Paintings and Shallow Waters—The Case for Advancing Spinal Cord Imaging in Multiple Sclerosis

Abstract Full Text
JAMA Neurol. 2022;79(1):9-10. doi:10.1001/jamaneurol.2021.4245

This Viewpoint describes the importance of improving magnetic resonance imaging of the spinal cord as a diagnostic procedure in multiple sclerosis.

On the Brain

The Promise and Peril of the Patient Portal

Abstract Full Text
JAMA Neurol. 2022;79(1):11-12. doi:10.1001/jamaneurol.2021.4453

This essay describes the pros and cons of using a patient portal during a parent’s illness and subsequent death.

Original Investigation

Amyloid-Related Imaging Abnormalities in 2 Phase 3 Studies Evaluating Aducanumab in Patients With Early Alzheimer Disease

Abstract Full Text
open access
JAMA Neurol. 2022;79(1):13-21. doi:10.1001/jamaneurol.2021.4161

This secondary analysis of 2 phase 3 randomized clinical trials describes the radiographic and clinical characteristics of amyloid-related imaging abnormalities that occurred in the EMERGE and ENGAGE trials.

Noncontrast Computed Tomography vs Computed Tomography Perfusion or Magnetic Resonance Imaging Selection in Late Presentation of Stroke With Large-Vessel Occlusion

Abstract Full Text
open access has active quiz
JAMA Neurol. 2022;79(1):22-31. doi:10.1001/jamaneurol.2021.4082

This cohort study compares the clinical outcomes of patients with stroke who presented 6 to 24 hours after symptom onset and were selected for mechanical thrombectomy by noncontrast computed tomography vs those selected by computed tomography perfusion or magnetic resonance imaging.

Association of Plasma p-tau181 and p-tau231 Concentrations With Cognitive Decline in Patients With Probable Dementia With Lewy Bodies

Abstract Full Text
has audio
JAMA Neurol. 2022;79(1):32-37. doi:10.1001/jamaneurol.2021.4222

This cohort study measures the concentrations of plasma p-tau (p-tau181 and p-tau231) and evaluates their associations with cognitive decline in individuals with probable dementia with Lewy bodies.

Transient Focal Neurological Events in Cerebral Amyloid Angiopathy and the Long-term Risk of Intracerebral Hemorrhage and Death: A Systematic Review and Meta-analysis

Abstract Full Text
has active quiz
JAMA Neurol. 2022;79(1):38-47. doi:10.1001/jamaneurol.2021.3989

This systematic review and individual participant meta-analysis examines factors associated with incident lobar intracerebral hemorrhage and death in patients with cerebral amyloid angiopathy–associated transient focal neurological episodes.

Research Criteria for the Behavioral Variant of Alzheimer Disease: A Systematic Review and Meta-analysis

Abstract Full Text
open access
JAMA Neurol. 2022;79(1):48-60. doi:10.1001/jamaneurol.2021.4417

This systematic review and meta-analysis reviews literature on the behavioral variant of Alzheimer disease and uses the outcomes to propose research criteria for this syndrome.

Twenty-Year Change in Severity and Outcome of Ischemic and Hemorrhagic Strokes

Abstract Full Text
open access
JAMA Neurol. 2022;79(1):61-69. doi:10.1001/jamaneurol.2021.4346

This cohort study assesses secular changes in initial neurological severity and short-term functional outcomes of patients with acute stroke by sex using a large population.

Development and Validation of the 5-SENSE Score to Predict Focality of the Seizure-Onset Zone as Assessed by Stereoelectroencephalography

Abstract Full Text
JAMA Neurol. 2022;79(1):70-79. doi:10.1001/jamaneurol.2021.4405

This cohort study identifies predictors for focality of the seizure-onset zone in stereoelectroencephalography based on standard presurgical epilepsy investigation to develop a score to calculate the probability of identifying a focal seizure onset in stereoelectroencephalography.

Images in Neurology

Bilateral Trigeminal Myokymia in Chronic Inflammatory Demyelinating Polyneuropathy With Systemic Lupus Erythematosus–Sjögren Overlap Syndrome

Abstract Full Text
has multimedia
JAMA Neurol. 2022;79(1):80-81. doi:10.1001/jamaneurol.2021.4069

This case report describes a woman in her 20s who was diagnosed with systemic lupus erythematosus-Sjögren overlap syndrome and had chronic inflammatory demyelinating polyneuropathy. Her neurological examination showed the presence of myokymia in the muscles, bilaterally innervated by the trigeminal nerve.

Linear Radial Brainstem Enhancement in Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy

Abstract Full Text
JAMA Neurol. 2022;79(1):82-83. doi:10.1001/jamaneurol.2021.4054

This case report describes progressive gait difficulty, visual blurriness, tremor, and mild confusion deemed compatible with autoimmune glial fibrillary acidic protein astrocytopathy.

JAMA Neurology Clinical Challenge

Acute Myelopathy in a Man With Cutaneous Papules

Abstract Full Text
has active quiz
JAMA Neurol. 2022;79(1):84-85. doi:10.1001/jamaneurol.2021.4194

A 46-year-old man presented with acute-onset weakness of his bilateral lower limbs for 3 days, accompanied by ascending numbness to just below his nipples. Neurological examination revealed weakness in bilateral lower limbs, extensor plantar responses, and a sensory level at T6. What is your diagnosis?

Research Letter

Susceptibility-Weighted Imaging of Intravascular Lymphoma of the Central Nervous System

Abstract Full Text
JAMA Neurol. 2022;79(1):86-87. doi:10.1001/jamaneurol.2021.4391

This case series examines susceptibility-weighted imaging in patients who had intravascular lymphoma of the central nervous system.

Observation

Six Recurrent Amyloid-Related Imaging Abnormality Episodes in a Patient Treated With Aducanumab

Abstract Full Text
JAMA Neurol. 2022;79(1):87-89. doi:10.1001/jamaneurol.2021.3933

This case report describes a 67-year-old man with prodromal AD treated with aducanumab who developed amyloid-related imaging abnormality–vasogenic edema and –hemorrhage.

Comment & Response

Concerns Remain Regarding Ambient NO2 Exposure and the Risk of Parkinson Disease

Abstract Full Text
JAMA Neurol. 2022;79(1):89. doi:10.1001/jamaneurol.2021.4103

Concerns Remain Regarding Ambient NO2 Exposure and the Risk of Parkinson Disease—Reply

Abstract Full Text
JAMA Neurol. 2022;79(1):89-90. doi:10.1001/jamaneurol.2021.4106

Safety of Early Discontinuation of Antiseizure Medication After Acute Symptomatic Neonatal Seizures

Abstract Full Text
JAMA Neurol. 2022;79(1):90-91. doi:10.1001/jamaneurol.2021.4109

Safety of Early Discontinuation of Antiseizure Medication After Acute Symptomatic Neonatal Seizures—Reply

Abstract Full Text
JAMA Neurol. 2022;79(1):91-92. doi:10.1001/jamaneurol.2021.4112

Unconvincing Evidence of SARS-CoV-2–Associated Myositis in Autopsied Muscles

Abstract Full Text
JAMA Neurol. 2022;79(1):92. doi:10.1001/jamaneurol.2021.4336

Unconvincing Evidence of SARS-CoV-2–Associated Myositis in Autopsied Muscles—Reply

Abstract Full Text
JAMA Neurol. 2022;79(1):92-93. doi:10.1001/jamaneurol.2021.4339
Correction

Missing Additional Information

Abstract Full Text
free access
JAMA Neurol. 2022;79(1):93. doi:10.1001/jamaneurol.2021.4372

Error in Title

Abstract Full Text
free access
JAMA Neurol. 2022;79(1):93. doi:10.1001/jamaneurol.2021.4477

Error in Author Name

Abstract Full Text
free access
JAMA Neurol. 2022;79(1):93. doi:10.1001/jamaneurol.2021.4854
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2022;79(1):5. doi:10.1001/jamaneurol.2021.3748
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