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September 2020, Vol 77, No. 9, Pages 1060-1179


Rethinking Regional Neurologic Care in the Coronavirus Disease 2019 Era

Abstract Full Text
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JAMA Neurol. 2020;77(9):1061-1062. doi:10.1001/jamaneurol.2020.1956

This Viewpoint discusses ways to reduce overtriage for patients with neurologic disease and finding ways to care for patients at a distance during the coronavirus disease 2019 pandemic.

Addressing Health Disparities Among Minority Populations: Why Clinical Trial Recruitment Is Not Enough

Abstract Full Text
JAMA Neurol. 2020;77(9):1063-1064. doi:10.1001/jamaneurol.2020.1614

This Viewpoint discusses health care disparities among racial/ethnic minority populations, focusing on recruitment to clinical trials for Alzheimer disease.

On the Brain

Mostly Able

Abstract Full Text
JAMA Neurol. 2020;77(9):1065. doi:10.1001/jamaneurol.2020.0776

This essay discusses the experience of physicians with neurological disabilities navigating their work and careers.


Keep the Worms in the Mud

Abstract Full Text
JAMA Neurol. 2020;77(9):1066-1067. doi:10.1001/jamaneurol.2020.0519
Original Investigation

Comparison of 3 Treatment Strategies for Medication Overuse Headache: A Randomized Clinical Trial

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JAMA Neurol. 2020;77(9):1069-1078. doi:10.1001/jamaneurol.2020.1179

This randomized clinical trial compares 3 treatment strategies among patients with medication overuse headache in Denmark.

Clinical Characteristics and Outcomes in Patients With Coronavirus Disease 2019 and Multiple Sclerosis

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JAMA Neurol. 2020;77(9):1079-1088. doi:10.1001/jamaneurol.2020.2581

This cohort study describes the clinical characteristics and outcomes in patients with multiple sclerosis who contract COVID-19 and identifies factors associated with COVID-19 severity.

Hookworm Treatment for Relapsing Multiple Sclerosis: A Randomized Double-Blinded Placebo-Controlled Trial

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JAMA Neurol. 2020;77(9):1089-1098. doi:10.1001/jamaneurol.2020.1118

This randomized clinical trial assesses the effect of hookworm treatment on magnetic resonance imaging activity and T regulatory cells in British patients with relapsing multiple sclerosis.

Safety, Efficacy, and Feasibility of Intranasal Insulin for the Treatment of Mild Cognitive Impairment and Alzheimer Disease Dementia: A Randomized Clinical Trial

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JAMA Neurol. 2020;77(9):1099-1109. doi:10.1001/jamaneurol.2020.1840

This randomized clinical trial examines the safety, efficacy, and feasibility of intranasal insulin for the treatment of persons with mild cognitive impairment and Alzheimer disease dementia.

Comparative Effectiveness of Carotid Endarterectomy vs Initial Medical Therapy in Patients With Asymptomatic Carotid Stenosis

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JAMA Neurol. 2020;77(9):1110-1121. doi:10.1001/jamaneurol.2020.1427

This comparative effectiveness study describes the analytical strategy, methods, and results of a target trial emulation examining cohorts of US veterans with carotid stenosis.

Assessment of Systemic Delivery of rAAVrh74.MHCK7.micro-dystrophin in Children With Duchenne Muscular Dystrophy: A Nonrandomized Controlled Trial

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JAMA Neurol. 2020;77(9):1122-1131. doi:10.1001/jamaneurol.2020.1484

This nonrandomized controlled trial analyzes safety, biological, and functional outcomes associated with the infusion of rAAVrh74.MHCK7.micro-dystrophin gene transfer in a small group of patients with Duchenne muscular dystrophy.

Contribution of Relapse-Independent Progression vs Relapse-Associated Worsening to Overall Confirmed Disability Accumulation in Typical Relapsing Multiple Sclerosis in a Pooled Analysis of 2 Randomized Clinical Trials

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JAMA Neurol. 2020;77(9):1132-1140. doi:10.1001/jamaneurol.2020.1568

This secondary analysis of data from 2 randomized clinical trials examines the relative contribution of relapse-associated vs relapse-independent progression to overall confirmed disability accumulation in patients with multiple sclerosis and assesses respective baseline prognostic factors and outcomes of the 2 treatments.

Evaluation of a New Criterion for Detecting Prion Disease With Diffusion Magnetic Resonance Imaging

Abstract Full Text
JAMA Neurol. 2020;77(9):1141-1149. doi:10.1001/jamaneurol.2020.1319

This diagnostic study assesses the sensitivity and specificity of diffusion magnetic resonance imaging with a new criterion of at least 1 positive brain region for the diagnosis of sporadic Creutzfeldt-Jakob disease.

Analysis of Normal High-Frequency Intracranial Pressure Values and Treatment Threshold in Neurocritical Care Patients: Insights into Normal Values and a Potential Treatment Threshold

Abstract Full Text
JAMA Neurol. 2020;77(9):1150-1158. doi:10.1001/jamaneurol.2020.1310

This study investigates associations between intracranial pressure values and outcomes in neurocritical care patients.


Monitoring Clinical Course and Treatment Response in Chronic Inflammatory Demyelinating Polyneuropathy During Routine Care: A Review of Clinical and Laboratory Assessment Measures

Abstract Full Text
JAMA Neurol. 2020;77(9):1159-1166. doi:10.1001/jamaneurol.2020.0781

This narrative review provides an overview of specific outcomes that are appropriate for chronic inflammatory demyelinating polyneuropathy monitoring during routine clinical care and highlights the minimum clinically important difference, if known.

Images in Neurology

Tattoo Reaction—a Diagnostic Clue in Neurosarcoidosis

Abstract Full Text
JAMA Neurol. 2020;77(9):1167-1168. doi:10.1001/jamaneurol.2020.2017

This case report details a man who experienced neurosarcoidosis for which an early diagnostic clue was a skin reaction to a tattoo.

Spinal Cord Involvement in Adult-Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia

Abstract Full Text
JAMA Neurol. 2020;77(9):1169-1170. doi:10.1001/jamaneurol.2020.2204

This case report describes novel magnetic resonance imaging findings in a man with adult-onset leukoencephalopathy with axonal spheroids and pigmented glia.

JAMA Neurology Clinical Challenge

Encephalomyelitis and Lymphadenopathy in a Man in His Early 40s

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JAMA Neurol. 2020;77(9):1171-1172. doi:10.1001/jamaneurol.2020.1634

A 43-year-old man presents with spinal cord syndrome and generalized lymphadenopathy. Multiple enhancing lesions were detected both in brain and cervical cord. What is your diagnosis?

Research Letter

Changing Causes of US Neurological Disease Mortality From 1999 to 2017

Abstract Full Text
JAMA Neurol. 2020;77(9):1175-1177. doi:10.1001/jamaneurol.2020.1878

This study estimates neurological disease mortality rate trends in the US population from 1999 to 2017 as well as regionalized differences within the US.

Migraines During Pregnancy and the Risk of Maternal Stroke

Abstract Full Text
JAMA Neurol. 2020;77(9):1177-1179. doi:10.1001/jamaneurol.2020.1435

This cohort study examines the extent to which hypertensive disorders mediate the association between migraines and maternal stroke.


Error in the Biomarker Subsection

Abstract Full Text
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JAMA Neurol. 2020;77(9):1179. doi:10.1001/jamaneurol.2020.2416

Error in Author Names and Figure Labels

Abstract Full Text
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JAMA Neurol. 2020;77(9):1179. doi:10.1001/jamaneurol.2020.2579

Mislabeled Curves in a Figure

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JAMA Neurol. 2020;77(9):1179. doi:10.1001/jamaneurol.2020.2784
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
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JAMA Neurol. 2020;77(9):1060. doi:10.1001/jamaneurol.2019.3219