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September 2022, Vol 79, No. 9, Pages 833-951


Targeting Sleep and Circadian Function in the Prevention of Alzheimer Disease

Abstract Full Text
JAMA Neurol. 2022;79(9):835-836. doi:10.1001/jamaneurol.2022.1732

This Viewpoint assesses the need for more research on sleep and circadian dysfunctions in the development of Alzheimer disease, including potential prevention or mitigation methods that target sleep and circadian function.

The Shrinking Roles of Clinical Research and Education for Academic Neurologists

Abstract Full Text
JAMA Neurol. 2022;79(9):837-838. doi:10.1001/jamaneurol.2022.1892

This Viewpoint discusses the role of academic-appointed neurologists in clinical research, education, and revenue generation for academic medical centers.

On the Brain

Tell Them

Abstract Full Text
JAMA Neurol. 2022;79(9):839-840. doi:10.1001/jamaneurol.2022.2085

This essay describes a time the author counseled a dying patient and his wife about the best next steps for his care in the hospital.


Correct Diagnosis for the Proper Treatment of Acute Vertigo—Putting the Diagnostic Horse Before the Therapeutic Cart

Abstract Full Text
JAMA Neurol. 2022;79(9):841-843. doi:10.1001/jamaneurol.2022.1493

Time for a New Perspective on Intracerebral Hemorrhage

Abstract Full Text
JAMA Neurol. 2022;79(9):844-845. doi:10.1001/jamaneurol.2022.1988
Original Investigation

Efficacy of Benzodiazepines or Antihistamines for Patients With Acute Vertigo: A Systematic Review and Meta-analysis

Abstract Full Text
has audio
JAMA Neurol. 2022;79(9):846-855. doi:10.1001/jamaneurol.2022.1858

This systematic review and meta-analysis compares the efficacy of benzodiazepine or antihistamine treatment for patients with acute vertigo from any underlying cause.

One-Year Outcome Trajectories and Factors Associated with Functional Recovery Among Survivors of Intracerebral and Intraventricular Hemorrhage With Initial Severe Disability

Abstract Full Text
JAMA Neurol. 2022;79(9):856-868. doi:10.1001/jamaneurol.2022.1991

This secondary analysis of 2 phase 3 clinical trials evaluates 1-year functional recovery among patients with intracerebral and intraventricular hemorrhage and initial severe disability and assesses factors associated with long-term recovery.

Disease-Modifying Treatments and Time to Loss of Ambulatory Function in Patients With Primary Progressive Multiple Sclerosis

Abstract Full Text
JAMA Neurol. 2022;79(9):869-878. doi:10.1001/jamaneurol.2022.1929

This comparative effectiveness research study investigates the effectiveness of disease-modifying treatments in patients with primary progressive multiple sclerosis with or without active disease.

Association Between Standardized Mortality Ratio and Utilization of Care in US Veterans With Drug-Resistant Epilepsy Compared With All US Veterans and the US General Population

Abstract Full Text
JAMA Neurol. 2022;79(9):879-887. doi:10.1001/jamaneurol.2022.2290

This cohort study evaluates associations between mortality and health care utilization among US veterans with drug-resistant epilepsy.

Global Prevalence and Incidence of Tinnitus: A Systematic Review and Meta-analysis

Abstract Full Text
JAMA Neurol. 2022;79(9):888-900. doi:10.1001/jamaneurol.2022.2189

This systematic review and meta-analysis provides frequency estimates of tinnitus worldwide, overall, by sex, and by age.

Prevalence of Atherosclerotic Risk Factors Among Children and Young Adults With Arterial Ischemic Stroke

Abstract Full Text
JAMA Neurol. 2022;79(9):901-910. doi:10.1001/jamaneurol.2022.2077

This case-control study assesses hypertension, hyperlipidemia, obesity, smoking, and diabetes as risk factors associated with incident arterial ischemic stroke in children and young adults, stratified by decade of age.

Association of Chronic Kidney Disease With Risk of Intracerebral Hemorrhage

Abstract Full Text
JAMA Neurol. 2022;79(9):911-918. doi:10.1001/jamaneurol.2022.2299

This combined observational and genetic study investigates the association between chronic kidney disease and risk of spontaneous intracerebral hemorrhage.

Association of Genetic Variant Linked to Hemochromatosis With Brain Magnetic Resonance Imaging Measures of Iron and Movement Disorders

Abstract Full Text
JAMA Neurol. 2022;79(9):919-928. doi:10.1001/jamaneurol.2022.2030

This cross-sectional study tests the association of the strongest genetic risk variant for hereditary hemochromatosis on brainwide measures sensitive to iron deposition and the rates of movement disorders in a large sample from the UK Biobank.

Special Communication

Six Action Steps to Address Global Disparities in Parkinson Disease: A World Health Organization Priority

Abstract Full Text
free access has active quiz
JAMA Neurol. 2022;79(9):929-936. doi:10.1001/jamaneurol.2022.1783

This Special Communication discusses findings from a World Health Organization consultation workshop on global disparities in Parkinson disease, including 6 workable avenues for action: disease burden; advocacy and awareness; prevention and risk reduction; diagnosis, treatment, and care; caregiver support; and research.


Focal Cooling for Drug-Resistant Epilepsy: A Review

Abstract Full Text
has active quiz
JAMA Neurol. 2022;79(9):937-944. doi:10.1001/jamaneurol.2022.1936

This narrative review presents the most current evidence supporting focal cooling in epilepsy and offers a brief overview of the technical challenges related to focal cooling in humans, including the optimal device design and cooling parameters.

Images in Neurology

Cortical Hemiballismus Associated With an Insular and Temporal Lobe Infarct

Abstract Full Text
has active quiz has multimedia
JAMA Neurol. 2022;79(9):945-946. doi:10.1001/jamaneurol.2022.2305

This case report describes a 61-year-old man who developed left hemichorea-hemiballismus that resolved spontaneously in less than 48 hours.

JAMA Neurology Clinical Challenge

Diplopia and Ptosis in an Older Woman

Abstract Full Text
has active quiz
JAMA Neurol. 2022;79(9):947-948. doi:10.1001/jamaneurol.2022.1982

A 75-year-old woman presented with a 3-day history of progressive headache, right-sided ptosis, and binocular diplopia. She had normal visual acuity and an unremarkable dilated fundus examination. Laboratory results revealed an elevated C-reactive protein and erythrocyte sedimentation rate. What is your diagnosis?

Research Letter

Association Between a Distinctive Autoantibody-Associated Brainstem Sensory Syndrome and Immune Checkpoint Inhibitors

Abstract Full Text
JAMA Neurol. 2022;79(9):949-951. doi:10.1001/jamaneurol.2022.1824

This case series investigates the association of a segmental, facial, antibody-associated brainstem sensory syndrome with the immune checkpoint inhibitor pembrolizumab.

JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
free access
JAMA Neurol. 2022;79(9):833. doi:10.1001/jamaneurol.2021.3788