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December 2018, Vol 75, No. 12, Pages 1453-1575

In This Issue of JAMA Neurology

Highlights

Abstract Full Text
free access
JAMA Neurol. 2018;75(12):1453. doi:10.1001/jamaneurol.2017.2671
Viewpoint

Deciding on the Best Multiple Sclerosis TherapyTough Choices

Abstract Full Text
JAMA Neurol. 2018;75(12):1461-1462. doi:10.1001/jamaneurol.2018.2689

This Viewpoint encourages using the deliberative model in treating and communicating with patients with relapsing-remitting multiple sclerosis.

Precision Medicine in Neurocritical Care

Abstract Full Text
JAMA Neurol. 2018;75(12):1463-1464. doi:10.1001/jamaneurol.2018.3157

This Viewpoint discusses the application of precision medicine to neurocritical care, providing an overview of what has worked in the past to define a framework for advancing precision medicine more broadly in neurocritical care

Editorial

Stimulating Dialogue Through Treatment of Poststroke Aphasia With Transcranial Direct Current Stimulation

Abstract Full Text
JAMA Neurol. 2018;75(12):1465-1467. doi:10.1001/jamaneurol.2018.1751

Optimizing Prehospital Triage for Patients With Stroke Involving Large Vessel OcclusionThe Road Less Traveled

Abstract Full Text
JAMA Neurol. 2018;75(12):1467-1469. doi:10.1001/jamaneurol.2018.2323
Original Investigation

Transcranial Direct Current Stimulation vs Sham Stimulation to Treat Aphasia After StrokeA Randomized Clinical Trial

Abstract Full Text
has active quiz
JAMA Neurol. 2018;75(12):1470-1476. doi:10.1001/jamaneurol.2018.2287

This randomized clinical trial examines the futility of studying anodal transcranial direct current stimulation vs sham stimulation as an adjunctive intervention during speech therapy to improve speech production (naming) for older adults with long-term poststroke aphasia.

Modeling Stroke Patient Transport for All Patients With Suspected Large-Vessel Occlusion

Abstract Full Text
JAMA Neurol. 2018;75(12):1477-1486. doi:10.1001/jamaneurol.2018.2424

This modeling study examines strategies for optimal triage and transport of patients with suspected large-vessel occlusion stroke to the appropriate center to achieve optimal care.

Preventing Cognitive Decline in Black Individuals With Mild Cognitive ImpairmentA Randomized Clinical Trial

Abstract Full Text
JAMA Neurol. 2018;75(12):1487-1493. doi:10.1001/jamaneurol.2018.2513

This randomized clinical trial determines whether behavioral activation prevents cognitive and functional decline over 2 years in black individuals with mild cognitive impairment.

Effect of Dextroamphetamine on Poststroke Motor RecoveryA Randomized Clinical Trial

Abstract Full Text
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JAMA Neurol. 2018;75(12):1494-1501. doi:10.1001/jamaneurol.2018.2338

This randomized clinical trial evaluates the effect of dextroamphetamine combined with physiotherapy vs placebo and physiotherapy for improving poststroke motor recovery among patients with ischemic stroke.

Neuropsychological Outcomes of Children 1 Year After Pediatric Cardiac ArrestSecondary Analysis of 2 Randomized Clinical Trials

Abstract Full Text
JAMA Neurol. 2018;75(12):1502-1510. doi:10.1001/jamaneurol.2018.2628

This secondary analysis of results from 2 randomized clinical trials compares caregiver-reported functional outcome measures with performance-based neuropsychological assessments at 1 year among pediatric survivors of cardiac arrest who were initially comatose after return of circulation.

Association of Intracranial Hemorrhage Risk With Non–Vitamin K Antagonist Oral Anticoagulant Use vs Aspirin UseA Systematic Review and Meta-analysis

Abstract Full Text
open access has multimedia
JAMA Neurol. 2018;75(12):1511-1518. doi:10.1001/jamaneurol.2018.2215

This systematic review and meta-analysis of randomized clinical trials assesses the risk of intracranial hemorrhage with non–vitamin K antagonist oral anticoagulant use compared with aspirin use.

Association of Leucine-Rich Glioma Inactivated Protein 1, Contactin-Associated Protein 2, and Contactin 2 Antibodies With Clinical Features and Patient-Reported Pain in Acquired Neuromyotonia

Abstract Full Text
JAMA Neurol. 2018;75(12):1519-1527. doi:10.1001/jamaneurol.2018.2681

This combined clinical cohort and survey study examines associations between neuromyotonia and voltage-gated potassium channel–complex–specific antibodies and the consequences of neuromyotonia for quality of life.

Development of a New Classification System for Idiopathic Inflammatory Myopathies Based on Clinical Manifestations and Myositis-Specific Autoantibodies

Abstract Full Text
has active quiz
JAMA Neurol. 2018;75(12):1528-1537. doi:10.1001/jamaneurol.2018.2598

This cohort study uses data from the French myositis network to identify subgroups of idiopathic inflammatory myopathies and to develop a classification scheme using clinical and serologic information.

Brief Report

Association of Medication Nonadherence Among Adult Survivors of Stroke After Implementation of the US Affordable Care Act

Abstract Full Text
JAMA Neurol. 2018;75(12):1538-1541. doi:10.1001/jamaneurol.2018.2302

This study investigates whether the US Affordable Care Act is associated with medication affordability and adherence among middle-aged to older adults who have had a stroke.

Unique Gadolinium Enhancement Pattern in Spinal Dural Arteriovenous Fistulas

Abstract Full Text
JAMA Neurol. 2018;75(12):1542-1545. doi:10.1001/jamaneurol.2018.2605

This medical record review described a unique pattern of spinal cord gadolinium enhancement on magnetic resonance imaging in patients with spinal dural arteriovenous fistulas.

Special Communication

Definition and Consensus Diagnostic Criteria for NeurosarcoidosisFrom the Neurosarcoidosis Consortium Consensus Group

Abstract Full Text
JAMA Neurol. 2018;75(12):1546-1553. doi:10.1001/jamaneurol.2018.2295

This Special Communication from the Neurosarcoidosis Consortium Consensus Group describes the clinical manifestations and process of diagnosing neurosarcoidosis as well as the efforts to establish standard definitions and diagnostic criteria for this disease.

Review

Molecular Basis and Clinical Overview of McLeod Syndrome Compared With Other Neuroacanthocytosis SyndromesA Review

Abstract Full Text
JAMA Neurol. 2018;75(12):1554-1562. doi:10.1001/jamaneurol.2018.2166

This review discusses the clinical manifestations and molecular basis of McLeod syndrome in comparison with other neuroacanthoscytosis syndromes, provides a comprehensive listing of alleles with involvement in McLeod syndrome, and discusses molecular tools to elucidate the genetic cause of the syndrome.

Images in Neurology

Cerebral Atrophy and Leukoencephalopathy in a Young Man Presenting With Encephalitic Episodes

Abstract Full Text
JAMA Neurol. 2018;75(12):1563-1564. doi:10.1001/jamaneurol.2018.2333

This case report describes a rare neurodegenerative cause of an encephalopathic episode in a young man with cerebral atrophy and leukencephalopathy that initially appeared similar to meningitis.

NeurothekeomasMultiple Symmetric Tumors in Both Hands

Abstract Full Text
JAMA Neurol. 2018;75(12):1565. doi:10.1001/jamaneurol.2018.2610

This case report describes a 61-year-old man who had tumors that gradually increased size in both hands for 7 years.

JAMA Neurology Clinical Challenge

An Unusual Fundus Finding in a Teenage Girl

Abstract Full Text
JAMA Neurol. 2018;75(12):1566-1567. doi:10.1001/jamaneurol.2018.3108

A 16-year-old girl presents with unsteadiness of gait, frequent falls, and unusual fundoscopy results. What is your diagnosis?

Research Letter

Epidural Spinal Cord Stimulation Training and Sustained Recovery of Cardiovascular Function in Individuals With Chronic Cervical Spinal Cord Injury

Abstract Full Text
JAMA Neurol. 2018;75(12):1569-1571. doi:10.1001/jamaneurol.2018.2617

This cohort study evaluates the feasibility of daily customized epidural stimulation configurations targeted for cardiovascular function in individuals with chronic, cervical motor-complete spinal cord injury.

Comment & Response

What Is the Association With Dissociation?

Abstract Full Text
JAMA Neurol. 2018;75(12):1571-1572. doi:10.1001/jamaneurol.2018.3220

What is the Association With Dissociation?—Reply

Abstract Full Text
JAMA Neurol. 2018;75(12):1572-1573. doi:10.1001/jamaneurol.2018.3237

Reporting and Dissemination of Clinical Trials in Neurology

Abstract Full Text
JAMA Neurol. 2018;75(12):1573. doi:10.1001/jamaneurol.2018.3306

Reporting and Dissemination of Clinical Trials in Neurology—Reply

Abstract Full Text
JAMA Neurol. 2018;75(12):1573-1574. doi:10.1001/jamaneurol.2018.3309

Considerations on Retrospective Identification and Classification of Learning Disabilities

Abstract Full Text
JAMA Neurol. 2018;75(12):1574-1575. doi:10.1001/jamaneurol.2018.3330

Considerations on Retrospective Identification and Classification of Learning Disabilities—Reply

Abstract Full Text
JAMA Neurol. 2018;75(12):1575. doi:10.1001/jamaneurol.2018.3342
Correction

Redundant Wording in Results and P Value Discrepancy in Figure 1

Abstract Full Text
free access
JAMA Neurol. 2018;75(12):1575. doi:10.1001/jamaneurol.2018.3465

Incorrect Affiliation

Abstract Full Text
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JAMA Neurol. 2018;75(12):1575. doi:10.1001/jamaneurol.2018.3609
JAMA Neurology Masthead

JAMA Neurology

Abstract Full Text
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JAMA Neurol. 2018;75(12):1456. doi:10.1001/jamaneurol.2017.2672
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