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Multiple sclerosis (MS) is a heterogeneous autoimmune disease of the central nervous system. The identification of 4 different immunopathological subtypes of MS raises the question of whether these subtypes represent different patient subgroups that can be distinguished according to their leading mechanism of myelin destruction or whether this is a stage-dependent process in the development of lesions in a given patient.
To document intraindividual immunopathological and radiological homogeneity of 2 different lesions in a single patient with relapsing-remitting MS over time.
A neuropathological referral center for inflammatory demyelinating diseases of the central nervous system.
A 49-year-old woman with clinically definite relapsing-remitting MS.
Main Outcome Measures
Radiological and immunopathological analysis of MS lesions.
Identical pathological findings in 2 different MS lesions separated by more than 2 years were identified. These lesions displayed similar and distinct radiological features on cranial imaging.
In this patient we were able to show the same antibody/complement-mediated lesion pathological findings with compatible identical ring enhancement on T1-weighted magnetic resonance images and hypointense rims on T2-weighted images after an interval of 26 months. Our observations support the concept of intraindividual homogeneity of a given immunopathological MS subtype.
König FB, Wildemann B, Nessler S, et al. Persistence of Immunopathological and Radiological Traits in Multiple Sclerosis. Arch Neurol. 2008;65(11):1527–1532. doi:https://doi.org/10.1001/archneur.65.11.1527
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