[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Dec 2011

Paraneoplastic Syndrome of Inappropriate Antidiuretic Hormone Mimicking Limbic Encephalitis

Author Affiliations

Author Affiliations: Departments of Neurology (Drs Blondin and Harel) and Pathology (Dr Vortmeyer), Yale University School of Medicine, New Haven, Connecticut.

Arch Neurol. 2011;68(12):1591-1594. doi:10.1001/archneurol.2011.876

Objective To compare the features of paraneoplastic syndrome of inappropriate antidiuretic hormone with those of limbic encephalitis.

Design Case study.

Setting Academic medical center.

Patient A 46-year-old woman with progressive memory impairment, hyponatremia, and seizures.

Interventions Magnetic resonance imaging of the brain, fluoro-2-deoxyglucose positron emission tomography of the body, and immunohistochemical analysis of a resected tumor.

Results Though the patient presented with clinical features of classic limbic encephalitis, magnetic resonance imaging, electroencephalogram, and cerebrospinal fluid analysis findings were unremarkable. Her chronic hyponatremia was ultimately found to be due to ectopic secretion of antidiuretic hormone by a neuroendocrine tumor with Merkel cell carcinoma phenotype.

Conclusions Patients presenting with memory impairment, seizures, and hyponatremia should undergo a thorough workup for occult malignancy. In addition to considering classic immune-mediated paraneoplastic limbic encephalitis, the ectopic secretion of antidiuretic hormone should be included in the differential diagnosis.