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Mobley and RosenbergArticle predict that we are on the cusp of what promises to be an era of unprecedented progress in neurology. Even with current fiscal constraints and serious concerns about how health care will be organized and financed, in the next 2 decades progress in neurology and neurological science will create important new insights into understanding the brain as we decipher its disorders and discover and apply effective treatments.
Hartung and DihnéArticle hypothesize that pathologic cerebrospinal fluid alterations are not just passive indicators of brain diseases but that they actively and directly evoke functional disturbances in global brain activity through the distribution of neuroactive substances, for instance, secondary to focal neurologic disease. For this mechanism, we propose the new term volume transmission–mediated encephalopathies.
This Month in Archives of Neurology. Arch Neurol. 2012;69(3):300–301. doi:10.1001/archneurol.2011.1444
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