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Chronic Cerebrospinal Venous Insufficiency and Multiple Sclerosis
Chronic cerebrospinal venous insufficiency has recently been proposed to be etiologic to multiple sclerosis. Bagert et alArticle indicate that an independent investigation into this theory during the past 2 years has not succeeded in verifying this relationship. A critical analysis of the scientific methods used in the original studies of chronic cerebrospinal venous insufficiency in multiple sclerosis reveals several methodological problems with regard to potential bias and confounding. The current evidence calls into question whether chronic cerebrospinal venous insufficiency in multiple sclerosis exists at all.
Cholesterol Level and Statin Use in Alzheimer Disease: II. Review of Human Trials and Recommendations
Shepardson and colleaguesArticle identify several confounding factors among the human studies, including differing blood-brain barrier permeabilities among statins, the stage in Alzheimer disease at which statins were administered, and the drugs' pleiotropic metabolic effects, all of which contribute to the substantial variability observed to date.
Coping With Death and Dying on a Neurology Inpatient Service: Death Rounds as an Educational Initiative for Residents
Khot et alArticle developed Death Rounds to provide emotional support and end-of-life care teaching for residents caring for dying patients on the inpatient neurology service. Death Rounds are monthly 1-hour clinical case discussions where residents identify issues through shared experiences. Death Rounds afford an opportunity for physicians-in-training to process as a group their feelings, intense emotions, and insecurities while learning from the dying process. Most residents found it a rewarding and valuable experience.
Association Between In Vivo Fluorine 18–Labeled Flutemetamol Amyloid Positron Emission Tomography Imaging and In Vivo Cerebral Cortical Histopathology
Wolk and colleaguesArticle demonstrate the concordance of fluorine 18–labeled flutemetamol amyloid positron emission tomography imaging with histopathology, supporting its sensitivity to detect amyloid and potential use in the study and detection of Alzheimer disease. Editorial perspective is provided by William Jagust, MDArticle.
Using Positron Emission Tomography and Florbetapir F 18 to Image Cortical Amyloid in Patients With Mild Cognitive Impairment or Dementia Due to Alzheimer Disease
The findings of the analysis by Fleisher and colleaguesArticle confirm the ability of florbetapir F 18 positron emission tomographic standard uptake value ratios to characterize amyloid levels in clinically probable Alzheimer disease, mild cognitive impairment, and older healthy control groups using continuous and binary measures of fibrillar Aβ burden. Editorial perspective is provided by William Jagust, MDArticle.
Repeated Treatment With Rituximab Based on the Assessment of Peripheral Circulating Memory B Cells in Patients With Relapsing Neuromyelitis Optica Over 2 Years
Kim et alArticle show that repeated treatment with rituximab appeared to produce consistent and sustained efficacy over 24 months with good tolerability in patients with neuromyelitis optica.
Interferon Beta-1b for the Treatment of Primary Progressive Multiple Sclerosis: Five-Year Clinical Trial Follow-up
Tur and colleaguesArticle find that modest but beneficial effects of interferon beta-1b on clinical variables and brain atrophy development were observed 5 years after trial termination.
Natalizumab and Impedance of the Homing of CD34+ Hematopoietic Progenitors
Saure et alArticle report that natalizumab mediates an increase in circulating CD34+ cells by interfering with homing to the bone marrow. Thus, CD34+ cells appear unlikely to represent a source mobilizing JC virus out of the bone marrow in patients treated with natalizumab.
Brain Involvement in Neuromyelitis Optica Spectrum Disorders
Chan and colleaguesArticle show that brain involvement manifesting clinically as brainstem encephalitis is common among Hong Kong Chinese patients with neuromyelitis optica spectrum disorders.
SQSTM1 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
Using candidate gene identification based on prior biological knowledge and the functional prediction of rare variants, Fecto et alArticle identified several novel SQSTM1 mutations in patients with amyotrophic lateral sclerosis. Their findings provide evidence of a direct genetic role for p62 in amyotrophic lateral sclerosis pathogenesis and suggest that regulation of protein degradation pathways may represent an important therapeutic target in motor neuron degeneration.
Prefrontal Cortex and Executive Function Impairments in Primary Breast Cancer
Kesler and colleaguesArticle provide further evidence of neurologic impairment associated with primary breast cancer irrespective of treatment history.
Relationship Between Chronic Atrial Fibrillation and Worse Outcomes in Stroke Patients After Intravenous Thrombolysis
Seet et alArticle find that patients with chronic atrial fibrillation have worse stroke outcomes than do patients without atrial fibrillation, and the risk for worse outcomes was greater in patients with a longer duration of atrial fibrillation.
This Month in Archives of Neurology. Arch Neurol. 2011;68(11):1371–1372. doi:10.1001/archneurol.2011.1499
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