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This Month in Archives of Neurology
Aug 2012

This Month in Archives of Neurology

Arch Neurol. 2012;69(8):957-958. doi:10.1001/archneurol.2011.1469

HonigArticle discusses the application of translational research to both diagnosis and treatment of dementia disorders. The development of biomarkers has yielded imaging and biochemical methods that assist the physician more than ever in the diagnosis of neurodegenerative dementias, especially Alzheimer disease. New diagnostic criteria for disease are based on these molecular-based techniques.

Emmanuele and colleaguesArticle noted that coenzyme Q10 (CoQ10) deficiency has been associated with 5 major clinical phenotypes: encephalomyopathy, severe infantile multisystemic disease, nephropathy, cerebellar ataxia, and isolated myopathy. They conducted a review of 149 cases, including their cohort of 76 patients, to study the heterogeneity of CoQ10 deficiency. Identification of CoQ10 deficiency is important because the condition frequently responds to treatment.