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Dementia Resulting From Traumatic Brain Injury: What Is the Pathology?
Shively and colleaguesArticle review the epidemiologic data linking traumatic brain injury and dementia and the existing clinical and pathologic data, and they identify areas where future research is needed.
Histopathologic features of chronic traumatic encephalopathy in a former professional football player (courtesy of Ann McKee, MD, Center for the Study of Traumatic Encephalopathy, Boston University School of Medicine, Boston, Massachusetts). Scanning view of the hippocampus and parahippocampal cortex. Note intense immunostaining of the entire Ammon horn and subiculum with focal involvement at the depths of sulci of the inferior temporal lobe.
Potential Use of γ-Secretase Modulators in the Treatment of Alzheimer Disease
Wagner et alArticle discuss γ-secretase inhibition and γ-secretase modulation as approaches to disease-modifying therapeutics capable of substantially altering the clinical course of Alzheimer disease and emphasize their significant differences.
Impact of Fingolimod Therapy on Magnetic Resonance Imaging Outcomes in Patients With Multiple Sclerosis
Radue and colleaguesArticle report fingolimod therapy resulted in rapid and sustained reductions in inflammatory lesion activity as assessed by gadolinium-enhancing and new/newly enlarged T2 lesions after 6, 12, and 24 months of therapy (P < .001, all comparisons vs placebo).
Comprehensive Search for Alzheimer Disease Susceptibility Loci in the APOE Region
Jun et alArticle indicate that APOE alleles ϵ2, ϵ3, and ϵ4 account for essentially all the inherited risk of Alzheimer disease associated with this region. Other variants including a poly-T track in TOMM40 are not independent risk or age at onset loci. Editorial perspective is provided by Rita J. Guerreiro, PhD, and John Hardy, PhDArticle.
Fingolimod Impedes Schwann Cell–Mediated Myelination: Implications for the Treatment of Immune Neuropathies?
Köhne and colleaguesArticle show that fingolimod can induce apoptosis in Schwann cells and may interfere with peripheral nerve myelination.
Results of Phase 2 Safety and Feasibility Study of Treatment With Levetiracetam for Prevention of Posttraumatic Epilepsy
Klein et alArticle provide data in support of further evaluation of levetiracetam treatment for the prevention of posttraumatic epilepsy.
Dying for the Weekend: A Retrospective Cohort Study on the Association Between Day of Hospital Presentation and the Quality and Safety of Stroke Care
Palmer and colleaguesArticle report evidence suggesting that the quality for care of stroke patients declines on weekends.
Inhibition of Interferon-beta Responses in Multiple Sclerosis Immune Cells Associated With High-Dose Statins
Feng et alArticle find that high-dose add-on statin therapy significantly reduces interferon-beta function and type 1 interferon responses in relapsing-remitting multiple sclerosis patients.
Plasma Biomarkers Associated With the Apolipoprotein E Genotype and Alzheimer Disease
Soares and colleaguesArticle confirm cerebrospinal fluid studies reporting increased levels of pancreatic polypeptide and N-terminal protein B–type brain natriuretic peptide in patients with Alzheimer disease and mild cognitive impairment.
Blood-Based Protein Biomarkers for Diagnosis of Alzheimer Disease
Doecke et alArticle identify a panel of plasma biomarkers that distinguish individuals with Alzheimer disease from cognitively healthy control subjects with high sensitivity and specificity.
Pathologic Accumulation of α-Synuclein and Aβ in Parkinson Disease Patients With Dementia
Kotzbauer and colleaguesArticle provide data indicating that dementia associated with Parkinson disease has 2 major pathologic subgroups: neocortical synucleinopathy and neocortical synucleinopathy with Aβ deposition.
Association of Shorter Leukocyte Telomere Repeat Length With Dementia and Mortality
Honig et alArticle suggest that shortened leukocyte telomere length is associated with risks for dementia and mortality and may therefore be a marker of biological aging.
Diffusion Tensor Imaging of Vascular Parkinsonism: Structural Changes in Cerebral White Matter and the Association With Clinical Severity
Wang and colleaguesArticle suggest that the disruption of the microstructural organization of frontal lobe white matter is associated with the severity of vascular parkinsonism.
This Month in Archives of Neurology. Arch Neurol. 2012;69(10):1237–1238. doi:10.1001/archneurol.2011.1479
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