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Inosine to Increase Urate in Parkinson Disease
The Parkinson Study Group SURE-PD Investigators determine the safety, tolerability, and urate-elevating capability of the urate precursor inosine in early Parkinson disease and assess its suitability and potential design features for a disease-modification trial.
Continuing Medical Education
Proximal Intracranial Arterial Occlusions
In a prospective cohort study at 2 university-based hospitals between 2003 and 2005, Lima and coauthors investigate the outcomes of patients who had an acute ischemic stroke attributable to an anterior circulation proximal intracranial arterial occlusion.
Author Audio Interview, Continuing Medical Education
Hematoma Expansion After Intracerebral Hemorrhage
Brouwers and colleagues develop a 9-point prediction score for hematoma expansion in patients with primary intracerebral hemorrhage. They perform a prospective cohort study at 2 urban academic medical centers among patients with available baseline and follow-up computed tomography. The prediction score was derived based on the regression estimates and was subsequently tested in an independent validation cohort.
Hematoma Expansion in Intracerebral Hemorrhage
Beslow and coauthors assess the frequency and extent of hematoma expansion in children with nontraumatic intracerebral hemorrhage.
Motor Neurons in Frontotemporal Lobar Degeneration (FTLD)
Riku and colleagues investigate a pathological continuity between FTLD-TDP and amyotrophic lateral sclerosis by comparing their respective neuropathological changes in the motor neuron system.
Clusterin in Amyloid-β–Associated Neurodegeneration
Desikan and coauthors aim to elucidate the relationship between clusterin, amyloid-β, phosphorylated tau, and rate of brain atrophy over time among nondemented older individuals.
Early Betaine Treatment and MTHFR Deficiency
Diekman et al investigate the effect of betaine treatment on development and survival in patients with severe methylenetetrahydrofolate reductase (MTHFR) deficiency.
Cholesterol and Cerebral Amyloidosis
Reed and colleagues investigate the association between serum cholesterol levels and cerebral β-amyloid early in the Alzheimer disease process.
Hypothyroidism and Cognitive Impairment
Parsaik and coauthors evaluate the association of clinical and subclinical hypothyroidism with mild cognitive impairment in a large population-based cohort.
DCTN1 Mutation Analysis
Caroppo and coauthors analyze the DCTN1 gene in families with a progressive supranuclear palsy–like phenotype at a referral center among 21 patients. In addition, 8 patients and relatives from a family carrying a DCTN1 mutation were evaluated. Outcome measures were identification of the DCTN1 mutation and clinical description of DCTN1 mutation carriers.
Effect of TMEM106B Polymorphism in GRN Carriers
Premi and colleagues ascertain whether TMEM106B genetic status modulates GRN disease by evaluating resting-state functional connectivity in aGRN+ according to TMEM106 genetic variation.
Clinical Review & Education
Innate Immune System After Ischemic Injury
Innate immune cells are critically involved in ischemic complications of atherosclerosis. Courties and coauthors describe the immune response after stroke and myocardial infarction.
Highlights. JAMA Neurol. 2014;71(2):131–133. doi:10.1001/jamaneurol.2013.4131
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