Customize your JAMA Network experience by selecting one or more topics from the list below.
Carotid Artery Atherosclerosis and Risk of Stroke
Bos and coauthors investigate the relationship between intracranial carotid artery calcification as a marker of intracranial atherosclerosis and the risk of stroke in a white population.
Continuing Medical Education
Growth and Impact of Alzheimer Disease Centers
Hughes and colleagues quantitatively evaluate the performance of Alzheimer disease centers by analyzing copublication networks among the centers.
Blood Test for Variant Creutzfeldt-Jakob Disease
Jackson et al determine the diagnostic accuracy of a prototype blood test for variant Creutzfeldt-Jakob disease and its suitability for clinical use and screening prion-exposed populations.
Parkinson Disease Risk Loci and Parkinsonian Signs
Shulman and colleagues evaluate 18 candidate single-nucleotide polymorphisms to determine whether Parkinson disease susceptibility loci are associated with parkinsonism or substantia nigra pathology.
Natalizumab vs Fingolimod in MS
Cohen and coauthors collect data from patients with multiple sclerosis (MS) switching from natalizumab to fingolimod. They performed a survey-based, observational multicenter cohort study among MS tertiary referral centers. Main outcomes and measures were the occurrence of MS relapse during the washout period or during a 6-month follow-up period after the initiation of fingolimod.
Phosphorylated Tau as a Biomarker for ALS
Grossman et al conduct a case-control study using phosphorylated tau to identify a biomarker for amyotrophic lateral sclerosis (ALS).
TREM2 Expression in Amyotrophic Lateral Sclerosis
Cady and coauthors investigate whether p.R47H (rs75932628) in TREM2 is a risk factor for amyotrophic lateral sclerosis and assess whether TREM2 expression is dysregulated in disease.
Brief Potentially Ictal Rhythmic Discharges
Yoo and colleagues evaluate the incidence of brief ictal rhythmic discharges in critically ill patients and investigate their association with seizures and outcomes.
Circadian Melatonin Rhythm in Parkinson Disease
Videnovic et al examine the endogenous circadian rhythm of melatonin secretion in patients with Parkinson disease and healthy control individuals using a modified constant routine protocol to assess human endogenous rhythmicity.
Clinical Phenotype Associated With ELOVL4 Mutation
Cadieux-Dion and coauthors map and identify the causative gene in a large French-Canadian family with autosomal dominant spinocerebellar ataxia and erythrokeratodermia variabilis.
Total vs Phosphorylated Tau in Creutzfeldt-Jakob
Skillbäck and colleagues test the diagnostic performance of dementia cerebrospinal fluid biomarkers total tau (T-tau), phosphorylated tau (P-tau), and the T-tau to P-tau ratio for Creutzfeldt-Jakob disease.
Clinical Review & Education
PGD for Genetic Prion Disorder
Uflacker et al describe the use of preimplantation genetic diagnosis and in vitro fertilization for the prevention of genetic prion disease in the children of a 27-year-old asymptomatic woman with a family history of Gerstmann-Sträussler-Scheinker syndrome.
Highlights. JAMA Neurol. 2014;71(4):383–385. doi:10.1001/jamaneurol.2013.4141
Coronavirus Resource Center
Create a personal account or sign in to: