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December 2015

Incorrect Statement in Discussion

Author Affiliations

Copyright 2015 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA Neurol. 2015;72(12):1537. doi:10.1001/jamaneurol.2015.4227

In the Original Investigation titled “Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle–Aged Adults at Risk for Alzheimer Disease,”1 published online July 27, 2015, and in the September 2015 print issue of JAMA Neurology, an incorrect statement appeared in the Discussion section. The report erroneously indicated that the lack of interaction with APOE ε4 was in contrast to an earlier study by Burns et al.2 In fact, the 2 sets of findings are similar, as Burns et al, who studied elevated fasting plasma glucose, also did not find an interaction with APOE ε4 genotype. Therefore, the ninth sentence of the second-to-last paragraph in the Discussion section that read, “Burns et al47 have also found interactions between hyperglycemia and APOE ε4 genotype on FDG-PET.” should be replaced with “Burns et al,47 however, found no interactions between hyperglycemia and APOE ε4 genotype on FDG-PET.” This article was corrected online.

Willette  AA, Bendlin  BB, Starks  EJ,  et al.  Association of insulin resistance with cerebral glucose uptake in late middle–aged adults at risk for Alzheimer disease.  JAMA Neurol. 2015;72(9):1013-1020.PubMedGoogle ScholarCrossref
Burns  CM, Chen  K, Kaszniak  AW,  et al.  Higher serum glucose levels are associated with cerebral hypometabolism in Alzheimer regions.  Neurology. 2013;80(17):1557-1564.PubMedGoogle ScholarCrossref