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In This Issue of JAMA Neurology
January 2017


JAMA Neurol. 2017;74(1):5. doi:10.1001/jamaneurol.2016.3974

Dean and colleagues assess associations between hallmark Alzheimer disease (AD) pathology and novel quantitative neuroimaging markers while being sensitive to white matter myelin content. Widespread age-related changes to myelin were observed across the brain, particularly in late myelinating brain regions such as frontal white matter and the genu of the corpus callosum. These findings suggest amyloid pathologies significantly influence white matter and that these abnormalities may signify an early feature of the disease process. Editorial perspective is provided by Gene E. Alexander, PhD.


Finke et al study cognitive outcome and structural magnetic resonance imaging alterations in patients with anti–leucine-rich, glioma-inactivated 1 (LGI1) encephalitis. Patients with anti-LGI1 encephalitis had incomplete recovery with significant and persisting verbal (mean [SE] Rey Auditory Verbal Learning Test, delayed recall: patients, 6.52 [1.05]; controls, 11.78 [0.56], P < .001) and visuospatial (Rey-Osterrieth Complex Figure Test, delayed recall: patients, 16.0 [1.96]; controls, 25.86 [1.24]; P < .001) memory deficits. They found that anti-LGI1 encephalitis is associated with cognitive deficits and disability as a result of structural damage to the hippocampal memory system. This damage might be prevented by early immunotherapy. Editorial perspective is provided by Gregory S. Day, MD, MSc, FRCPC.