We conducted a prospective cohort study derived from the population-based Mayo Clinic Study of Aging, which is an ongoing study of normal cognitive aging and mild cognitive impairment (MCI) among persons 70 years or older.
In our analyses, we compared mentally stimulating activities performed at least 1 to 2 times per week vs mentally stimulating activities performed 2 to 3 times per month or less (reference group) in predicting the risk of incident mild cognitive impairment. The model was adjusted for sex, age (scale), and educational level. Additional adjustment for medical comorbidity and depression did not significantly alter the results.
eTable 1. Mentally Stimulating Activities and Risk of Incident Amnestic/Nonamnestic MCI
eTable 2. Interaction Between Mentally Stimulating Activities and APOE ε4 Status on the Risk of Incident MCI
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Krell-Roesch J, Vemuri P, Pink A, et al. Association Between Mentally Stimulating Activities in Late Life and the Outcome of Incident Mild Cognitive Impairment, With an Analysis of the APOE ε4 Genotype. JAMA Neurol. 2017;74(3):332–338. doi:10.1001/jamaneurol.2016.3822
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Does engaging in a mentally stimulating activity in old age associate with neurocognitive function?
In this population-based cohort study, 1929 cognitively normal participants 70 years or older were followed for approximately 4 years. The following activities were associated with significant decreased risk of new-onset mild cognitive impairment: computer use, craft activities, social activities, and playing games.
Engaging in a mentally stimulating activity even in late life may decrease the risk of mild cognitive impairment.
Cross-sectional associations between engagement in mentally stimulating activities and decreased odds of having mild cognitive impairment (MCI) or Alzheimer disease have been reported. However, little is known about the longitudinal outcome of incident MCI as predicted by late-life (aged ≥70 years) mentally stimulating activities.
To test the hypothesis of an association between mentally stimulating activities in late life and the risk of incident MCI and to evaluate the influence of the apolipoprotein E (APOE) ε4 genotype.
Design, Setting, and Participants
This investigation was a prospective, population-based cohort study of participants in the Mayo Clinic Study of Aging in Olmsted County, Minnesota. Participants 70 years or older who were cognitively normal at baseline were followed up to the outcome of incident MCI. The study dates were April 2006 to June 2016.
Main Outcomes and Measures
At baseline, participants provided information about mentally stimulating activities within 1 year before enrollment into the study. Neurocognitive assessment was conducted at baseline, with evaluations at 15-month intervals. Cognitive diagnosis was made by an expert consensus panel based on published criteria. Hazard ratios (HRs) and 95% CIs were calculated using Cox proportional hazards regression models after adjusting for sex, age, and educational level.
The final cohort consisted of 1929 cognitively normal persons (median age at baseline, 77 years [interquartile range, 74-82 years]; 50.4% [n = 973] female) who were followed up to the outcome of incident MCI. During a median follow-up period of 4.0 years, it was observed that playing games (HR, 0.78; 95% CI, 0.65-0.95) and engaging in craft activities (HR, 0.72; 95% CI, 0.57-0.90), computer use (HR, 0.70; 95% CI, 0.57-0.85), and social activities (HR, 0.77; 95% CI, 0.63-0.94) were associated with a decreased risk of incident MCI. In a stratified analysis by APOE ε4 carrier status, the data point toward the lowest risk of incident MCI for APOE ɛ4 noncarriers who engage in mentally stimulating activities (eg, computer use: HR, 0.73; 95% CI, 0.58-0.92) and toward the highest risk of incident MCI for APOE ɛ4 carriers who do not engage in mentally stimulating activities (eg, no computer use: HR, 1.74; 95% CI, 1.33-2.27).
Conclusions and Relevance
Cognitively normal elderly individuals who engage in specific mentally stimulating activities even in late life have a decreased risk of incident MCI. The associations may vary by APOE ε4 carrier status.
Dementia has become a global epidemic, causing substantial burden not only for society but also for caregivers and patient families.1 Therefore, it is critical to examine potential protective lifestyle-related factors against cognitive decline and dementia, preferably based on cohort studies involving large sample sizes.
Various terms have been used to describe activities that keep the mind active and may contribute to healthy aging. Indeed, cognitive, intellectual, or mentally stimulating activities are associated with a decreased risk of cognitive decline2 and dementia.3-10 To date, few studies have investigated whether cognitive activities are related to the outcome of mild cognitive impairment (MCI), which is the intermediate zone between normal cognitive aging and dementia.11 Our group has reported a cross-sectional association between mentally stimulating activities and decreased odds of having MCI.12 A cohort study involving a convenience sample of community-dwelling elderly found an association between cognitive activities and a decreased risk of amnestic MCI,13 as well as vascular cognitive impairment.14
In the present population-based cohort study, we sought to determine whether engaging in mentally stimulating activities in late life could be of potential benefit in reducing the risk of incident MCI in persons 70 years or older. The study dates were April 2006 to June 2016. We have made rigorous efforts to ensure that our study participants were cognitively normal at baseline, and we had a well-established research infrastructure to follow up the cohort to the outcome of incident MCI. Such an undertaking minimizes potential for reverse causality, although theoretically it may not completely eliminate it. We hypothesized that elderly persons who report engaging in mentally stimulating activities at least 1 to 2 times per week have a significantly decreased risk of developing new-onset MCI compared with persons who report fewer mentally stimulating activities. Because apolipoprotein E (APOE) ε4 carrier status is a well-known risk factor for MCI and dementia,15-18 we also conducted a stratified analysis by APOE ε4 genotype. We hypothesized that (1) APOE ε4 carriers have a higher risk of developing incident MCI compared with APOE ε4 noncarriers regardless of engaging in mentally stimulating activities and (2) APOE ε4 carriers who report engaging in mentally stimulating activities have a decreased risk of developing incident MCI compared with APOE ε4 carriers who do not report engaging in mentally stimulating activities.
We conducted a prospective cohort study derived from the population-based Mayo Clinic Study of Aging (MCSA). The MCSA is an ongoing study of normal cognitive aging and MCI among persons 70 years or older. Details of the MCSA have been reported elsewhere.19 Briefly, from the target population of 9953 elderly individuals residing in Olmsted County, Minnesota, on October 1, 2004, we recruited study participants by stratified random sampling.20 The MCSA protocols were approved by the institutional review boards of the Mayo Clinic and Olmsted Medical Center in Rochester, Minnesota. All participants provided written informed consent.
We assembled a cohort of 2213 cognitively normal participants who had completed a questionnaire on engaging in mentally stimulating activities, as well as a valid cognitive assessment at baseline. Neurocognitive assessment at baseline was followed by evaluations at 15-month intervals. In total, 284 individuals were excluded (242 withdrew before follow-up, 3 had no follow-up visit, and 39 died before follow-up). Therefore, the final cohort consisted of 1929 cognitively normal persons who were followed up to the outcome of incident MCI.
Details of the measurement of mentally stimulating activities in the MCSA have been reported elsewhere.12,21 Briefly, we modified previously validated instruments to measure these activities.8,22,23 We defined the following activities as exposures of interest based on the results from our group’s cross-sectional study12: reading books, craft activities, computer use, playing games, and social activities (eg, going out to movies and theaters). A research nurse or psychometrist assessed the frequency at which each participant engaged in each mentally stimulating activity by using a structured survey with ordinal responses (once per month or less, 2-3 times per month, 1-2 times per week, 3-4 times per week, 5-6 times per week, or daily). Participants were asked to provide information about engagement in these activities in the year before study participation (late-life mentally stimulating activities).
The cognitive assessment in the MCSA is described in detail elsewhere.12,19 Briefly, a face-to-face evaluation was completed among all study participants and included the following 3 assessment components: (1) a neurological evaluation, which included a neurological history review, the administration of the Short Test of Mental Status,24 and a neurological examination; (2) a risk factor assessment interview, which was conducted by a nurse or study coordinator and included the Clinical Dementia Rating Scale; and (3) neuropsychological testing, which was administered by a psychometrist to assess performance in 4 cognitive domains. These 4 domains were (1) memory (delayed recall trials from the Auditory Verbal Learning Test25 and Wechsler Memory Scale–Revised26 logical memory and visual reproduction subtests), (2) language (Boston Naming Test27,28 and category fluency29), (3) visuospatial skills (Wechsler Adult Intelligence Scale–Revised30 picture completion and block design subtests), and (4) executive functions (Trail Making Test B31 and Wechsler Adult Intelligent Scale–Revised30 digit symbol substitution subtest).
An expert consensus panel made the classifications of normal cognition and MCI after reviewing the results acquired from the clinical and neuropsychological evaluation.19 Individuals were considered cognitively normal at baseline according to published normative data developed on this community.32-35 For MCI, the following revised Mayo Clinic criteria for MCI36,37 were used: (1) cognitive concern expressed by a physician, informant, participant, or nurse; (2) impairment in 1 or more cognitive domains (memory, language, visuospatial skills, or executive functions); (3) essentially normal functional activities; and (4) absence of dementia. Participants with MCI had a Clinical Dementia Rating Scale score of 0 or 0.5; however, the final diagnosis of MCI was based on all available data.
Blood was drawn from the study participants after receiving written informed consent. DNA was amplified by means of polymerase chain reaction, and APOE ε4 genotyping was determined by standard methods.38 The genotypes were assessed by laboratory technicians who were kept unaware of clinical characteristics.
To investigate the association between late-life mentally stimulating activities and the outcome of incident MCI, we calculated hazard ratios (HRs) and 95% CIs. We used Cox proportional hazards regression models, with age as a timescale and after adjusting for sex, educational level, medical comorbidity (weighted Charlson Comorbidity Index),39 depression (Beck Depression Inventory–II score <13 vs ≥13),40 and APOE ε4 carrier status.
Hypotheses were generated from our group’s previous cross-sectional study.12 Therefore, the analyses were conducted separately for the following 5 types of mentally stimulating activities in late life (within 1 year of the cognitive assessment): reading books, playing games, craft activities, computer use, and social activities (eg, going out to movies and theaters). In our analyses, we compared mentally stimulating activities performed at least 1 to 2 times per week vs mentally stimulating activities performed 2 to 3 times per month or less (reference group) in predicting the risk of incident MCI. We measured central tendency using medians and associated interquartile ranges (IQRs). Furthermore, we conducted analyses stratified by MCI subtype (amnestic vs nonamnestic), as well as APOE ε4 carrier status to investigate possible interactions between this genetic risk factor for Alzheimer disease (AD) and mentally stimulating activities in late life. Fitting all the data, we also tested for multiplicative interactions on the HR scale, as well as for additive interactions. Statistical testing was performed at the conventional 2-tailed α = .05. All analyses were performed using statistical software (SAS, version 9.3; SAS Institute Inc).
At baseline, we included 1929 cognitively normal persons 70 years or older (50.4% [n = 973] female) who had completed a valid assessment of mentally stimulating activities and a cognitive evaluation. We followed up this cohort for a median of 4.0 years (IQR, 2.3-6.4 years), at which time 456 participants had developed new-onset MCI (Figure 1). The median age at baseline was 77 years (IQR, 74-82 years), and the median educational level was 14 years (IQR, 12-16 years). In total, 512 participants (26.7%) were APOE ɛ4 carriers; APOE ε4 genotype data were missing for 9 participants. The detailed demographic characteristics are listed in Table 1.
After adjusting for sex, age, and educational level, we observed that playing games (HR, 0.78; 95% CI, 0.65-0.95) and engaging in craft activities (HR, 0.72; 95% CI, 0.57-0.90), computer use (HR, 0.70; 95% CI, 0.57-0.85), and social activities (HR, 0.77; 95% CI, 0.63-0.94) were associated with a decreased risk of incident MCI. The association between reading books (HR, 0.83; 95% CI, 0.68-1.01) and a decreased risk of incident MCI approached significance. Additional adjustment for medical comorbidity, depression, and APOE ε4 genotype did not significantly alter the results (model 2). Table 2 summarizes these results.
We also conducted stratified analyses by MCI subtype (amnestic vs nonamnestic). We observed significant associations between craft activities (HR, 0.76; 95% CI, 0.58-1.00), computer use (HR, 0.75; 95% CI, 0.59-0.95), and social activities (HR, 0.74; 95% CI, 0.58-0.95) and a decreased risk of incident amnestic MCI. However, we observed a significant association only between computer use (HR, 0.42; 95% CI, 0.26-0.67) and a decreased risk of incident nonamnestic MCI. The results of this analysis are summarized in eTable 1 in the Supplement.
We conducted the same analyses stratified by APOE ε4 carrier status. Among APOE ε4 noncarriers, craft activities (HR, 0.65; 95% CI, 0.49-0.85) and computer use (HR, 0.73; 95% CI, 0.58-0.93) were significantly associated with a decreased risk of incident MCI. The associations approached significance for reading books (HR, 0.81; 95% CI, 0.64-1.02) and playing games (HR, 0.81; 95% CI, 0.64-1.02). Among APOE ε4 carriers, only computer use (HR, 0.65; 95% CI, 0.46-0.92) and social activities (HR, 0.62; 95% CI, 0.43-0.89) were associated with a decreased risk of incident MCI (Table 3).
We also examined a possible interaction between late-life mentally stimulating activities and APOE ε4 genotype in predicting the risk of incident MCI. We defined the reference group as participants who did not engage in late-life mentally stimulating activities and were APOE ε4 noncarriers. We consistently observed the lowest risk of incident MCI in participants who engaged in any type of mentally stimulating activity and were APOE ε4 noncarriers compared with the reference group. In contrast, participants who were APOE ε4 carriers and did not engage in mentally stimulating activities tended to have the highest risk for incident MCI, with the exception of engaging in craft activities. None of the results of tests for additive interactions between late-life mentally stimulating activities and the APOE ε4 genotype on the risk of new-onset MCI were significant. However, the model on additive interaction approached significance for social activities. Additional adjustment for medical comorbidity and depression did not alter the results. eTable 2 in the Supplement summarizes these results, and Figure 2 shows an HR plot of the data.
In this population-based prospective cohort study, we observed that engaging in mentally stimulating activities in late life was associated with a decreased risk of incident MCI. More specifically, playing games and engaging in craft activities, computer use, and social activities significantly reduced the risk of incident MCI. In the past, our group has reported decreased odds of MCI associated with engagement in mentally stimulating activities in late life in a population-based case-control study.12 However, those findings were considered preliminary until confirmed by a prospective cohort study, which we are reporting herein.
When comparing MCI subtypes (amnestic vs nonamnestic), we observed more associations between mentally stimulating activities and a decreased risk of amnestic MCI than nonamnestic MCI. This finding could be explained by limited power because of smaller sample size for the analysis on nonamnestic MCI.
Because the APOE ε4 genotype is a well-known risk factor for MCI and AD,15-18 we also conducted stratified analyses by APOE ε4 carrier status in predicting the outcome of incident MCI. As expected, the data point toward a reduced risk of incident MCI for APOE ɛ4 noncarriers who engage in mentally stimulating activities. However, we observed fewer associations between mentally stimulating activities and a decreased risk of incident MCI for APOE ɛ4 carriers compared with noncarriers. This finding may in part be explained by a smaller sample size of APOE ɛ4 carriers, which limits the statistical power of this analysis.
Our study findings are in line with previous research that reported a potentially protective effect of mentally stimulating activities on cognitive decline,2 dementia,3-10 and MCI.13,21 In addition, a recent study21 involving persons 85 years or older reported a list of risk and protective factors for advanced aging, one of which was an association between cognitive activities and a decreased risk of MCI. To our knowledge, the present study may be one of few population-based cohort studies (if not the first) to examine the risk of incident MCI in persons 70 years or older as predicted by engagement in mentally stimulating activities in late life.
Our study could not disentangle why some mentally stimulating activities (eg, computer use) had a larger effect size on the decreased risk of incident MCI than other activities (eg, reading books). However, we speculate that a particular mental activity (eg, computer use) may require specific technical and manual skills and that these could be the factors that might be associated with a decreased risk of cognitive decline. Future studies may need to examine the specific mediation factors between a particular mentally stimulating activity and the decreased risk of incident MCI.
However, we did not investigate possible mechanisms that might underlie the association between engagement in mentally stimulating activities and the risk of incident MCI. Insights on these mechanisms can be derived from animal studies. Investigations involving mouse models of AD showed a protective effect of enriched environments on neuropathological changes associated with AD, such as prevention of neuronal dysfunction and increased synaptic recovery.41 Thus far, few studies have investigated the associations between mental or cognitive activities and pathological changes associated with cognitive decline and AD in humans. For example, researchers at the University of California, Berkeley, reported a significant association between cognitive activities and a decreased β-amyloid deposition in the cortex.42 An Australian group found that complex mental activity across the life span was associated with decreased hippocampal atrophy.43 A recent report indicated that higher cognitive reserve was associated with decreased age-related changes in cerebrospinal fluid biomarkers.44 In addition, one can hypothesize that engagement in mentally stimulating activities may be associated with other protective lifestyle factors, such as engagement in physical exercise. These activities might in sum lead to a decreased risk of cognitive decline.12 Also, the cognitive reserve theory states that engagement in mentally stimulating activities or a high educational level may buffer the negative effects of abnormal brain pathological changes on cognitive function.45 The reader is referred to our group’s previous article12 for a discussion of potential mechanisms of action.
In addition to mentally stimulating activities, several other risk and protective factors for MCI have been discussed in the literature. There is evidence that neuropsychiatric symptoms46,47 are associated with an increased risk of incident MCI. In contrast, lifestyle-related factors, such as physical exercise48 and low caloric intake,49 are associated with a lower risk of MCI.
The findings of our study should be interpreted within the context of its strengths and limitations. The major strength of our study pertains to its design. We conducted a population-based prospective cohort study with a large sample size of 1929 participants at baseline, whom we followed up for several years. In addition, MCI was assessed using face-to-face evaluations and was based on a consensus panel at the Alzheimer Disease Research Center at Mayo Clinic in Rochester, which has a well-known reputation in the field.
A limitation pertains to potential recall bias that stems from the questionnaire on self-reported mentally stimulating activities. Also, we did not control for mentally stimulating activities performed in early life or mid-life. We can assume that individuals who engaged in mentally stimulating activities in early life or mid-life are more likely to engage in these activities in late life compared with persons who did not engage in these activities during the life span. Furthermore, an observational study like ours allows investigating associations but does not permit drawing conclusions about cause and effect, which can only be done by interventional (experimental) studies. Therefore, we cannot exclude a “reverse causality” explanation (ie, it is possible that participants who are at higher risk for MCI are less likely to engage in mentally stimulating activities). However, given that we conducted a rigorous, time-intensive, large-scale population-based prospective cohort study, and considering similar findings from smaller studies in the past, we can conclude that the observed associations in our study are real. In addition, most of the population in Olmsted County is of white race. However, generalizability of the data to the population of the United States has been indicated.50
We observed that engaging in mentally stimulating activities even in late life may be protective against new-onset MCI. In addition, performing certain mentally stimulating activities may also lower the risk of incident MCI among APOE ɛ4 carriers. Future research is needed to understand the mechanisms linking mentally stimulating activities and cognition in late life.
Corresponding Author: Yonas E. Geda, MD, MSc, Mayo Clinic Translational Neuroscience and Aging Program, Mayo Clinic, Collaborative Research Bldg, 13400 E Shea Blvd, Scottsdale, AZ 85259 (firstname.lastname@example.org).
Accepted for Publication: August 8, 2016.
Published Online: January 30, 2017. doi:10.1001/jamaneurol.2016.3822
Author Contributions: Dr Geda had full access to all data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Krell-Roesch, Roberts, Petersen, Geda.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Krell-Roesch, Geda.
Critical revision of the manuscript for important intellectual content: Vemuri, Pink, Roberts, Stokin, Mielke, Christianson, Knopman, Petersen, Kremers.
Statistical analysis: Christianson, Kremers.
Administrative, technical, or material support: Roberts, Petersen, Geda.
Study supervision: Geda.
Conflict of Interest Disclosures: Dr Knopman reported being deputy editor of Neurology; reported serving on data safety monitoring boards for Lundbeck Pharmaceuticals, the Dominantly Inherited Alzheimer’s Disease Treatment Unit, and Lilly Pharmaceuticals; reported serving as a consultant to TauRx; reported being an investigator in clinical trials sponsored by Baxter and Elan Pharmaceuticals in the past 2 years; and reported receiving research support from the National Institutes of Health. Dr Petersen reported being a consultant to GE Healthcare and Elan Pharmaceuticals, reported serving on a data safety monitoring board in clinical trials sponsored by Pfizer Incorporated and Janssen Alzheimer Immunotherapy, and reported delivering a continuing medical education lecture at Novartis Incorporated. Dr Kremers reported receiving research funding from AstraZeneca. No other disclosures were reported.
Funding/Support: The study was supported by grants U01 AG006786 and R01 AG034676 from the National Institute on Aging and by grants K01 MH068351 and K01 AG028573 from the National Institute of Mental Health. Support for this research was also provided by the Robert Wood Johnson Foundation, the Robert H. and Clarice Smith and Abigail Van Buren Alzheimer’s Disease Research Program, the European Regional Development Fund–Project FNUSA-ICRC (No. CZ.1.05/1.1.00/02.0123), the Arizona Alzheimer’s Consortium, and the Edli Foundation (the Netherlands) (Dr Geda).
Role of the Funder/Sponsor: The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
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