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Previous studies have suggested that head trauma in men may be associated with testosterone deficiency and erectile dysfunction (ED) through mechanisms that likely include damage to the pituitary; however, it is not known if multiple concussive events are associated with more testosterone deficiency and a greater frequency of ED. Professional US-style football players may be at increased risk because of high numbers of head injuries experienced during their careers. In a cross-sectional study of 3409 former players, Grashow and coauthors found that concussion symptoms during professional play were significantly associated with current self-reported low testosterone levels and ED. Men who have experienced head injuries may benefit from discussions with their health care clinicians regarding these treatable conditions.
Highlights. JAMA Neurol. 2019;76(12):1411. doi:10.1001/jamaneurol.2018.3021
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