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Article
June 1964

Myoglobinuria

Author Affiliations

NEW YORK
Departments of Neurology and Biochemistry, College of Physicians and Surgeons, Columbia University; Neurological Clinical Research Center, Neurological Institute, Columbia-Presbyterian Medical Center, New York City, and Neurology Service, Department of Medicine, Wilford Hall USAF Hospital, Aerospace Medical Division (AFSC), Lackland Air Force Base, Texas.

Arch Neurol. 1964;10(6):537-562. doi:10.1001/archneur.1964.00460180003001
Abstract

Introduction  Human myoglobinuria has been regarded as a rare syndrome, but, as in other rare syndromes, increasing awareness has led to an increasing number of reports. The first description is usually attributed to Meyer-Betz in 1910,96 and there have been about 118 cases in the world literature until the present, 103 since 1951 (Table 1).The total of 118 is only an approximation because selection of cases has been somewhat arbitrary. On the one hand, the urinary pigment has not been strictly identified in all cases (although the clinical and pathological descriptions were felt to be compatible with the diagnosis). On the other hand, the compilation includes only those cases considered to be primarily "idiopathic," not those due to exogenous causes, but this distinction is not precise. Furthermore, some cases of probable myoglobinuria have been reported with other diagnoses and have not been included.43,48,49 It is a major

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As indicated in Table 6, Stein et al15,136 reported that normal plasma taurine concentrations range from 0.4—0.8 mg per 100 ml. Four myoglobinuric patients had concentrations greater than this, but in this laboratory the range in seven normal adults was 0.29—1.04 mg per 100 ml (mean 0.63). In six children under age 10 years the values are slightly higher (0.53—1.05 mg per 100 ml, mean 0.84). Frimpter et al45 have also found normal values higher than those originally reported.
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