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Article
August 1985

Adenovirus Type 2 Encephalitis and Concurrent Epstein-Barr Virus Infection in an Adult Man

Author Affiliations

From the Division of Infectious Diseases, Department of Medicine (Drs West and Parker), the Department of Medical Medical Technology (Dr Papasian), and the Department of Pediatrics (Dr Park), State University of New York at Buffalo, School of Medicine.

Arch Neurol. 1985;42(8):815-817. doi:10.1001/archneur.1985.04210090083023
Abstract

A 30-year-old bisexual male prisoner with a historyy of intravenous drug abuse manifested encephalitis. Adenovirus type 2 was isolated from brain tissue obtained by a biopsy and there was a concurrent fourfold rise in the antibody titer. In addition, an initial negative result from a slide test for infectious mononucleosis heterophil antibodies (Monospot) test converted to positive and there was an increase in the IgG antibodyy titer to Epstein-Barr virus (EBV) viral capsid antigen. Although he was anergic to skin test antigens, T-cell subsets and lymphocyte transformation study results were normal. This case demonstrated a rare adenovirus encephalitis with a simultaneous EBV infection in a patient at risk for acquired immunodeficiency syndrome, who had minimal evidence of T-cell deficiency.

References
1.
Chany C, Lepine P, Lelong M, et al:  Severe and fatal pneumonia in infants and young children associated with adenovirus infections .  Am J Hyg 1958;67:367-378.
2.
Faulkner R, van Rooyen CE:  Adenoviruses types 3 and 5 isolated from the cerebrospinal fluid of children .  Can Med Assoc J 1962;24:11231125.
3.
Gabrielson MO, Joseph C, Hsiung GD:  Encephalitis associated with adenovirus type 7 occurring in a family outbreak .  J Pediatr 1966; 68:142-144.Crossref
4.
Huttunen L:  Adenovirus type 7-associated encephalitis .  Scand J Infect Dis 1970;2:151-153.
5.
Simila S. Jouppila R. Salmi A, et al:  Encephalomeningitis in children associated with an adenovirus type 7 epidemic .  Acta Pediatr Scand 1970;59:310-316.Crossref
6.
Roos R, Chou SM, Rogers NG, et al:  Isolation of an adenovirus 32 strain from human brain in a case of subacute encephalitis .  Proc Soc Exp Biol Med 1972;139:636-640.Crossref
7.
Chou SM, Roos R, Burrell R, et al:  Subacute focal adenovirus encephalitis . J Neuropathol Exp Neurol 1973;32:34-50.Crossref
8.
Lord A, Sutton RNP, Corsellis JAN:  Recovery of adenovirus type 7 from human brain cell cultures .  J Neurol Neurosurg Psychiatry 1975; 38:710-712.Crossref
9.
Kelsey DS:  Adenovirus meningoencephalitis .  Pediatrics 1978;61:291-293.
10.
Kim KS, Gohd RS:  Acute encephalopathy in twins due to adenovirus type 7 infection .  Arch Neurol 1983;40:58-59.Crossref
11.
Koskiniemi ML, Vaheri A:  Acute encephalitis of viral origin .  Scand J Infect Dis 1982; 14:181-187.
12.
Kasel JA:  Adenoviruses , in Lennette EH, Schmidt NJ (eds):  Diagnostic Procedures for Viral, Rickettsial, and Chlamydial Infections , ed 5. Washington, DC, American Public Health Association, 1979, pp 229-256.
13.
Gottlieb MS, Schroff R, Schanker HM, et al:  Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men .  N Engl J Med 1981;305:1425-1431.Crossref
14.
Harris C, Small CB, Klein RS, et al:  Immunodeficiency in female sexual partners of men with the acquired immunodeficiency syndrome .  N Engl J Med 1983;308:1181-1184.Crossref
15.
Wormser GP, Krupp LB, Hanrahan JP, et al:  Acquired Immunodeficiency syndrome in male prisoners .  Ann Intern Med 1983;98:297-303.Crossref
16.
De Jong PJ, Spigland I, Valderrama G, et al:  Adenovirus isolates from urine of patients with acquired immunodeficiency syndrome .  Lancet 1983;1:1293-1296.Crossref
17.
Rogers MF, Morens DM, Stewart JA, et al:  National case-control study of Kaposi's sarcoma and Pneumocystis carinii pneumonia in homosexual men: II. Laboratory results .  Ann Intern Med 1983;99:151-158.Crossref
18.
 Update on acquired immune deficiency syndrome (AIDS): United States .  MMWR 1982; 31:507-508, 513-514.
19.
Metroka CE, Cunningham-Rundles S, Pollack MS, et al:  Generalized lymphadenopathy in homosexual men .  Ann Intern Med 1983;99:585-591.Crossref
20.
Tosato G, Magrath I, Koski I, et al:  Activation of suppressor T cells during Epstein-Barrvirus-induced infectious mononucleosis .  N Engl J Med 1979;301:1133-1137.Crossref
21.
Weigle KA, Sumaya CV, Montiel MM:  Changes in T-lymphocyte subsets during childhood Epstein-Barr virus infectious mononucleosis .  J Clin Immunol 1983;3:151-155.Crossref
22.
Grose C, Henle W, Henle G, et al:  Primary Epstein-Barr-virus infections in acute neurologic diseases .  N Engl J Med 1975;292:392-395.Crossref
23.
Silverstein A, Steinberg G, Nathanson M:  Nervous system involvement in infectious mononucleosis .  Arch Neurol 1972;26:353-358.Crossref
24.
Gilbert JW, Culebras A:  Cerebellitis in infectious mononucleosis .  JAMA 1972;220:727.Crossref
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