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September 1989

Magnesium Sulfate in the Treatment of Eclampsia

Author Affiliations

Department of Obstetrics and Gynecology University of Texas Southwestern Medical Center 5323 Harry Hines Blvd Dallas, TX 75235

Arch Neurol. 1989;46(9):947-948. doi:10.1001/archneur.1989.00520450017010

To the Editor.  —I challenge the conclusion reached by Hachinski in his report entitled "Magnesium Sulfate in the Treatment of Eclampsia," published in the December issue of the Archives1 in the "Controversies in Neurology" section in the segment entitled "Does Magnesium Sulfate Treat Eclamptic Seizures?" He states: "Until such time as we have a better grasp of the pathophysiology of eclampsia or more credible clinical results, the use of magnesium sulfate should be relegated to the laboratory, a clinical trial, or history."Let us consider "a better grasp of the pathophysiology of eclampsia." Easily stated but yet to be accomplished! For four decades I have been treating women with eclampsia while waiting for the time when "the pathophysiology of eclampsia" was finally delineated. Without the benefit of a clear understanding of the "pathophysiology of eclampsia" I was obligated to manage cases of eclampsia (and even to advise others on

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Kaplan PW, Lesser RP, Fisher RS, Repke JT, Hanley DF.  No, magnesium sulfate should not be used in treating eclamptic seizures .  Arch Neurol . 1988;45:1361-1364.Crossref
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Dinsdale HB.  Does magnesium sulfate treat eclamptic seizures? Yes .  Arch Neurol . 1988;45:1360-1361.Crossref