Oculomotor Phenotypes in Autosomal Dominant Ataxias | Genetics and Genomics | JAMA Neurology | JAMA Network
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Original Contribution
October 1998

Oculomotor Phenotypes in Autosomal Dominant Ataxias

Author Affiliations

From the Department of Neurology (Drs Buttner, Geschwind, Jen, Perlman, Pulst, and Baloh), Neurogenetics Program (Drs Geschwind, Jen, and Baloh), and Division of Head and Neck Surgery (Dr Baloh), UCLA School of Medicine, Los Angeles, Calif; and Department of Neurology, Cedars-Sinai Medical Center, Los Angeles (Dr Pulst).

Arch Neurol. 1998;55(10):1353-1357. doi:10.1001/archneur.55.10.1353
Abstract

Objective  To quantify the oculomotor features of the common spinocerebellar ataxia (SCA) syndromes.

Setting  University ataxia clinic.

Patients  Twenty probands with documented SCA mutations.

Methods  Electro-oculographic recordings of saccadic, smooth pursuit, optokinetic, vestibular, and visual-vestibular eye movements.

Results  Distinct phenotype and genotype patterns were identified with modest overlap between patterns. Slowing of saccade peak velocities occurred only in SCA1 and SCA2, being present in 100% of patients with SCA2. Impaired vestibulo-ocular reflex gain occurred with SCA3 only. Patients with SCA6 had prominent deficits in smooth tracking but normal saccade velocities and vestibulo-ocular reflex gain.

Conclusions  The oculomotor findings are consistent with pure cerebellar involvement in SCA6, pontine involvement in SCA1 and SCA2, and vestibular nerve or nuclei involvement in SCA3. These phenotypes can be useful for clinical diagnosis and for investigating the mechanism of system specificity with the SCA syndromes.

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