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This Month in Archives of Neurology
December 1999

This Month in Archives of Neurology

Arch Neurol. 1999;56(12):1439-1440. doi:10.1001/archneur.56.12.1439

MarkesberyArticle reviews the critical evidence for oxidative stress that is an essential ingredient contributing to the cause of Alzheimer disease. Future potential therapy will need to address this issue.

O'Dell and colleaguesArticle outline a thoughtful analysis of how the phenotype of a cell from a diseased individual can be identified and defined through RNA amplification methods. Differences in the pattern of relative messenger RNA levels from damaged and normal cells can provide detailed information about the molecular state of individual cells and patients, leading to potential designer pharmacotherapy in the future. This is a provoking and important concept with obvious potential.