The Correlation Between Ventricular Diameter Measured by Transcranial Sonography and Clinical Disability and Cognitive Dysfunction in Patients With Multiple Sclerosis | Demyelinating Disorders | JAMA Neurology | JAMA Network
[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 35.170.64.36. Please contact the publisher to request reinstatement.
1.
Noseworthy  JHPaty  DWEbers  GC Neuroimaging in multiple sclerosis.  Neurol Clin. 1984;2759- 777Google Scholar
2.
De Stefano  NNarayanan  SPelletier  DFrancis  GSAntel  JPArnold  DL Evidence of early axonal damage in patients with multiple sclerosis.  Neurology. 1999;52(suppl 2)A378Google Scholar
3.
Losseff  NAMiller  DH Measures of brain and spinal cord atrophy in multiple sclerosis.  J Neurol Neurosurg Psychiatry. 1998;64Suppl 1S102- S105Google Scholar
4.
Losseff  NAWang  LLai  HM  et al.  Progressive cerebral atrophy in multiple sclerosis: a serial MRI study.  Brain. 1996;119 ((pt 6)) 2009- 2019Google ScholarCrossref
5.
Nijeholt  GJvan Walderveen  MACastelijns  JA  et al.  Brain and spinal cord abnormalities in multiple sclerosis: correlation between MRI parameters, clinical subtypes and symptoms.  Brain. 1998;121 ((pt 4)) 687- 697Google ScholarCrossref
6.
Filippi  MPaty  DWKappos  L  et al.  Correlations between changes in disability and T2-weighted brain MRI activity in multiple sclerosis: a follow-up study.  Neurology. 1995;45255- 260Google ScholarCrossref
7.
Fisher  ERudick  RATkach  JA  et al.  Automated calculation of whole brain atrophy from magnetic resonance imaging for monitoring multiple sclerosis.  Neurology. 1999;52(suppl 2)A352Google ScholarCrossref
8.
Rudick  RAFisher  ELee  JCSimon  JJacobs  LMultiple Sclerosis Collaborative Research Group, Use of brain parenchymal fraction to measure whole brain atrophy in relapsing-remitting MS.  Neurology. 1999;531698- 1704Google ScholarCrossref
9.
Miller  DHSimon  JHRudick  RAJacobs  LD Determinants of brain atrophy in relapsing multiple sclerosis.  Neurology. 1999;52(suppl 2)A357Google ScholarCrossref
10.
Simon  JHJacobs  LDCampion  MK  et al.  A longitudinal study of brain atrophy in relapsing multiple sclerosis.  Neurology. 1999;53139- 148Google ScholarCrossref
11.
Becker  GBogdahn  UStrassburg  HM  et al.  Identification of ventricular enlargement and estimation of intracranial pressure by transcranial color-coded real-time sonography.  J Neuroimaging. 1994;417- 22Google Scholar
12.
Bogdahn  UedBecker  GedSchlachetzki  Fed Echoenhancers and Transcranial Color Duplex Sonography.  Boston, Mass Blackwell Science1998;323- 331
13.
Kurtzke  JF Rating neurological impairment in multiple sclerosis: an Expanded Disability Rating Scale (EDSS).  Neurology. 1983;331444- 1452Google ScholarCrossref
14.
Bever  CT  JrGrattan  LPanitch  HSJohnson  KP The Brief Repeatable Battery of Neuropsychological Tests for Multiple Sclerosis: a preliminary serial study.  Mult Scler. 1995;1165- 169Google Scholar
15.
Montgomery  SAÅsberg  M A new depression scale designed to be sensitive to change.  Br J Psychiatry. 1979;134382- 389Google ScholarCrossref
16.
Collegium Internationale Psychiatriae Scalarum (CIPS), Rating Scales for Psychiatry.  Weinheim, Germany Beltz1990;
17.
Fleiss  JLShrout  PE The effects of measurement errors on some multivariate procedures.  Am J Public Health. 1977;671188- 1191Google ScholarCrossref
18.
Seidel  GKaps  MGerriets  THutzelmann  A Evaluation of the ventricular system in adults by transcranial Duplex sonography.  J Neuroimaging. 1995;5105- 108Google Scholar
19.
Pozzilli  CPassafiume  DBernadi  S  et al.  SPECT, MRI and cognitive functions in multiple sclerosis.  J Neurol Neurosurg Psychiatry. 1991;54110- 115Google ScholarCrossref
20.
Rao  SMGlatt  SHammeke  A  et al.  Chronic progressive multiple sclerosis: relationship between cerebral ventricular size and neuropsychological impairment.  Arch Neurol. 1985;42678- 682Google ScholarCrossref
21.
Trapp  BDPeterson  JRansohoff  RMRudick  RMork  SBo  L Axonal transection in the lesions of multiple sclerosis.  N Engl J Med. 1998;338278- 285Google ScholarCrossref
22.
Goodkin  DEPriore  RLWende  KEand The Multiple Sclerosis Collaborative Research Group, Comparing the ability of various compositive outcomes to discriminate treatment effects in MS clinical trails.  Mult Scler. 1998;4480- 486Google ScholarCrossref
Original Contribution
September 2000

The Correlation Between Ventricular Diameter Measured by Transcranial Sonography and Clinical Disability and Cognitive Dysfunction in Patients With Multiple Sclerosis

Author Affiliations

From the Department of Neurology (Drs Berg, Mäurer, Rieckmann, and Becker) and the Division of Neuroradiology (Dr Warmuth-Metz), Bayerische Julius-Maximilians-Universität, Würzburg, Germany.

Arch Neurol. 2000;57(9):1289-1292. doi:10.1001/archneur.57.9.1289
Abstract

Context  Magnetic resonance imaging (MRI) data suggest that the extent of brain atrophy in patients with multiple sclerosis (MS) is related to the severity of disease.

Objective  To evaluate whether ventricular diameter determined by transcranial sonography (TCS) is a marker of brain atrophy and is correlated with disability, cognitive performance, and mood.

Subjects and Methods  We examined 74 subjects with MS and 74 age- and sex-matched control subjects with TCS and assessed the transverse diameter of the third ventricle and the frontal horns of the lateral ventricles. Quantitative neurological examination was performed in subjects with MS using the Expanded Disability Status Scale. All subjects with MS underwent MRI, the Brief Repeatable Battery of Neuropsychological Tests for MS, and standardized tests for mood disorders.

Results  Transcranial sonographic measurements of ventricular diameter closely matched MRI measurements (Spearman rank correlation, r=0.7-0.9; P<.01). The ventricular diameters were significantly larger in subjects with MS than in healthy age- and sex-matched control subjects. The measurement of the diameter of the third ventricle obtained by TCS or MRI and the measurement of disability obtained with the Expanded Disability Status Scale were significantly correlated (Spearman rank correlation, r = 0.4; P<.01). The correlation between the diameter of the frontal horns and disability was substantially lower for both neuroimaging techniques. In addition, TCS and MRI data correlated significantly with the majority of neuropsychological tests; no correlation was found between the diameter of the ventricles and depression scales.

Conclusion  As ventricular diameter is related to the status of disability and may also indicate disease progression, we propose measurement of the diameter of the third ventricle with TCS as a quick and easy surrogate marker for serial follow-up examinations in patients with MS.

×